Names & Taxonomy

Uniprot ID:
O15540
Entry Name:
FABP7_HUMAN
Status:
reviewed
Protein Names:
Fatty acid-binding protein, brain (Brain lipid-binding protein) (BLBP) (Brain-type fatty acid-binding protein) (B-FABP) (Fatty acid-binding protein 7) (Mammary-derived growth inhibitor related)
Gene Names:
FABP7 BLBP FABPB MRG
Gene Names Primary:
FABP7
Organism:
Homo sapiens (Human)

Structure

Length:
132
Sequence:
MVEAFCATWKLTNSQNFDEYMKALGVGFATRQVGNVTKPTVIISQEGDKVVIRTLSTFKNTEISFQLGEEFDETTADDRNCKSVVSLDGDKLVHIQKWDGKETNFVREIKDGKMVMTLTFGDVVAVRHYEKA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity).
Cross Reference Drug Bank:
DB00132 DB00154 DB00159 DB04224
Gene Ontology Go:
cell periphery
cell projection
cell-cell junction
cytoplasm
cytosol
neuronal cell body
nucleoplasm
lipid binding
transporter activity
cell proliferation in forebrain
epithelial cell proliferation
negative regulation of cell proliferation
nervous system development
neurogenesis
prepulse inhibition
small molecule metabolic process
triglyceride catabolic process
Gene Ontology Biological Process:
cell proliferation in forebrain
epithelial cell proliferation
negative regulation of cell proliferation
nervous system development
neurogenesis
prepulse inhibition
small molecule metabolic process
triglyceride catabolic process
Gene Ontology Molecular Function:
lipid binding
transporter activity
Gene Ontology Cellular Component:
cell-cell junction
cell periphery
cell projection
cytoplasm
cytosol
neuronal cell body
nucleoplasm
Keywords:
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Lipid-binding
Polymorphism
Reference proteome
Transport

Publication

PubMed ID:
9375786 9591779 14702039 17974005 14574404 15489334 10854433 12479569