Names & Taxonomy
- Uniprot ID:
- O15439
- Entry Name:
- MRP4_HUMAN
- Status:
- reviewed
- Protein Names:
- Multidrug resistance-associated protein 4 (ATP-binding cassette sub-family C member 4) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B)
- Gene Names:
- ABCC4 MRP4
- Gene Names Primary:
- ABCC4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1325
- Sequence:
- MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGKAEAAALTETAKQVYFKRNYPHIGHTDHMVTNTSNGQPSTLTIFETAL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- May be an organic anion pump relevant to cellular detoxification.
- Cross Reference Drug Bank:
- DB00718 DB00770 DB01076 DB01327 DB00482 DB02659 DB00286 DB00586 DB00917 DB00975 DB00544 DB00712 DB00158 DB08884 DB00143 DB01050 DB00328 DB01009 DB00709 DB00650 DB00814 DB01033 DB00563 DB00731 DB00198 DB01032 DB01098 DB00203 DB00398 DB01138 DB01268 DB00300 DB00352 DB01586 DB00661 DB00495
- Gene Ontology Go:
- basolateral plasma membrane
integral component of membrane
membrane
plasma membrane
platelet dense granule membrane
15-hydroxyprostaglandin dehydrogenase (NAD+) activity
ATP binding
ATPase activity, coupled to transmembrane movement of substances
blood coagulation
cilium assembly
oxidation-reduction process
platelet activation
platelet degranulation
prostaglandin secretion
transmembrane transport - Gene Ontology Biological Process:
- blood coagulation
cilium assembly
oxidation-reduction process
platelet activation
platelet degranulation
prostaglandin secretion
transmembrane transport - Gene Ontology Molecular Function:
- 15-hydroxyprostaglandin dehydrogenase (NAD+) activity
ATPase activity, coupled to transmembrane movement of substances
ATP binding - Gene Ontology Cellular Component:
- basolateral plasma membrane
integral component of membrane
membrane
plasma membrane
platelet dense granule membrane - Keywords:
- ATP-binding
Alternative splicing
Complete proteome
Glycoprotein
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport