Names & Taxonomy

Uniprot ID:
O15431
Entry Name:
COPT1_HUMAN
Status:
reviewed
Protein Names:
High affinity copper uptake protein 1 (Copper transporter 1) (hCTR1) (Solute carrier family 31 member 1)
Gene Names:
SLC31A1 COPT1 CTR1
Gene Names Primary:
SLC31A1
Organism:
Homo sapiens (Human)

Structure

Length:
190
Sequence:
MDHSHHMGMSYMDSNSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVELLFSGLVINTAGEMAGAFVAVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAVVVDITEHCH
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane in intestinal epithelial cells.

Function

Function:
High-affinity, saturable copper transporter involved in dietary copper uptake.
Cross Reference Drug Bank:
DB00188 DB00958 DB00515 DB00526
Gene Ontology Go:
integral component of plasma membrane
late endosome
neuronal cell body
plasma membrane
recycling endosome
copper ion transmembrane transporter activity
copper uptake transmembrane transporter activity
cellular copper ion homeostasis
cellular response to cisplatin
copper ion import into cell
copper ion transport
drug transmembrane transport
transmembrane transport
Gene Ontology Biological Process:
cellular copper ion homeostasis
cellular response to cisplatin
copper ion import into cell
copper ion transport
drug transmembrane transport
transmembrane transport
Gene Ontology Molecular Function:
copper ion transmembrane transporter activity
copper uptake transmembrane transporter activity
Gene Ontology Cellular Component:
integral component of plasma membrane
late endosome
neuronal cell body
plasma membrane
recycling endosome
Keywords:
3D-structure
Cell membrane
Complete proteome
Copper
Copper transport
Glycoprotein
Ion transport
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
9207117 14702039 17974005 15164053 15489334 11734551 17525160 16501047