Names & Taxonomy
- Uniprot ID:
- O15431
- Entry Name:
- COPT1_HUMAN
- Status:
- reviewed
- Protein Names:
- High affinity copper uptake protein 1 (Copper transporter 1) (hCTR1) (Solute carrier family 31 member 1)
- Gene Names:
- SLC31A1 COPT1 CTR1
- Gene Names Primary:
- SLC31A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 190
- Sequence:
- MDHSHHMGMSYMDSNSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVELLFSGLVINTAGEMAGAFVAVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAVVVDITEHCH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane in intestinal epithelial cells.
Function
- Function:
- High-affinity, saturable copper transporter involved in dietary copper uptake.
- Cross Reference Drug Bank:
- DB00188 DB00958 DB00515 DB00526
- Gene Ontology Go:
- integral component of plasma membrane
late endosome
neuronal cell body
plasma membrane
recycling endosome
copper ion transmembrane transporter activity
copper uptake transmembrane transporter activity
cellular copper ion homeostasis
cellular response to cisplatin
copper ion import into cell
copper ion transport
drug transmembrane transport
transmembrane transport - Gene Ontology Biological Process:
- cellular copper ion homeostasis
cellular response to cisplatin
copper ion import into cell
copper ion transport
drug transmembrane transport
transmembrane transport - Gene Ontology Molecular Function:
- copper ion transmembrane transporter activity
copper uptake transmembrane transporter activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
late endosome
neuronal cell body
plasma membrane
recycling endosome - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Copper
Copper transport
Glycoprotein
Ion transport
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport