Names & Taxonomy
- Uniprot ID:
- O15427
- Entry Name:
- MOT4_HUMAN
- Status:
- reviewed
- Protein Names:
- Monocarboxylate transporter 4 (MCT 4) (Solute carrier family 16 member 3)
- Gene Names:
- SLC16A3 MCT4
- Gene Names Primary:
- SLC16A3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 465
- Sequence:
- MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPEVAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
- Cross Reference Drug Bank:
- DB01440 DB04398 DB00627 DB00119
- Gene Ontology Go:
- actin cytoskeleton
integral component of plasma membrane
membrane
nuclear membrane
plasma membrane
lactate transmembrane transporter activity
monocarboxylic acid transmembrane transporter activity
poly(A) RNA binding
symporter activity
blood coagulation
cellular metabolic process
leukocyte migration
monocarboxylic acid transport
plasma membrane lactate transport
pyruvate metabolic process
small molecule metabolic process
transmembrane transport - Gene Ontology Biological Process:
- blood coagulation
cellular metabolic process
leukocyte migration
monocarboxylic acid transport
plasma membrane lactate transport
pyruvate metabolic process
small molecule metabolic process
transmembrane transport - Gene Ontology Molecular Function:
- lactate transmembrane transporter activity
monocarboxylic acid transmembrane transporter activity
poly(A) RNA binding
symporter activity - Gene Ontology Cellular Component:
- actin cytoskeleton
integral component of plasma membrane
membrane
nuclear membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Direct protein sequencing
Membrane
Phosphoprotein
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q8N9N5; Q8IZU0; Q86WQ0