Names & Taxonomy

Uniprot ID:
O15427
Entry Name:
MOT4_HUMAN
Status:
reviewed
Protein Names:
Monocarboxylate transporter 4 (MCT 4) (Solute carrier family 16 member 3)
Gene Names:
SLC16A3 MCT4
Gene Names Primary:
SLC16A3
Organism:
Homo sapiens (Human)

Structure

Length:
465
Sequence:
MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPEVAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
Cross Reference Drug Bank:
DB01440 DB04398 DB00627 DB00119
Gene Ontology Go:
actin cytoskeleton
integral component of plasma membrane
membrane
nuclear membrane
plasma membrane
lactate transmembrane transporter activity
monocarboxylic acid transmembrane transporter activity
poly(A) RNA binding
symporter activity
blood coagulation
cellular metabolic process
leukocyte migration
monocarboxylic acid transport
plasma membrane lactate transport
pyruvate metabolic process
small molecule metabolic process
transmembrane transport
Gene Ontology Biological Process:
blood coagulation
cellular metabolic process
leukocyte migration
monocarboxylic acid transport
plasma membrane lactate transport
pyruvate metabolic process
small molecule metabolic process
transmembrane transport
Gene Ontology Molecular Function:
lactate transmembrane transporter activity
monocarboxylic acid transmembrane transporter activity
poly(A) RNA binding
symporter activity
Gene Ontology Cellular Component:
actin cytoskeleton
integral component of plasma membrane
membrane
nuclear membrane
plasma membrane
Keywords:
Cell membrane
Complete proteome
Direct protein sequencing
Membrane
Phosphoprotein
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport
Interacts With:
Q8N9N5; Q8IZU0; Q86WQ0

Publication

PubMed ID:
9425115 14702039 15489334 17081983 18691976 18669648 20068231 21269460 25944712