Names & Taxonomy
- Uniprot ID:
- O15382
- Entry Name:
- BCAT2_HUMAN
- Status:
- reviewed
- Protein Names:
- Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT(m)) (EC 2.6.1.42) (Placental protein 18) (PP18)
- Gene Names:
- BCAT2 BCATM BCT2 ECA40
- Gene Names Primary:
- BCAT2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 392
- Sequence:
- MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform A: Mitochondrion.; Isoform B: Cytoplasm.
Function
- Function:
- Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.
- Catalytic Activity:
- L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.; L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate.; L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate.
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Cross Reference Drug Bank:
- DB00167 DB00149
- Gene Ontology Go:
- mitochondrial matrix
mitochondrion
branched-chain-amino-acid transaminase activity
L-isoleucine transaminase activity
L-leucine transaminase activity
L-valine transaminase activity
branched-chain amino acid biosynthetic process
branched-chain amino acid catabolic process
cellular nitrogen compound metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- branched-chain amino acid biosynthetic process
branched-chain amino acid catabolic process
cellular nitrogen compound metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- branched-chain-amino-acid transaminase activity
L-isoleucine transaminase activity
L-leucine transaminase activity
L-valine transaminase activity - Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrion - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Amino-acid biosynthesis
Aminotransferase
Branched-chain amino acid biosynthesis
Complete proteome
Cytoplasm
Mitochondrion
Polymorphism
Pyridoxal phosphate
Reference proteome
Transferase
Transit peptide