Names & Taxonomy
- Uniprot ID:
- A0A087WSZ2
- Entry Name:
- A0A087WSZ2_HUMAN
- Status:
- unreviewed
- Protein Names:
- Alpha-actinin-3
- Gene Names:
- ACTN3
- Gene Names Primary:
- ACTN3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 944
- Sequence:
- MGIGLCVPPARCWKRLTRSSRGQPLERPAATIIIGLSIVERSKQTQRGPVDFSRSHSAPAAEQECKPRISAARSTPAPPSPAVPGFRTTPCQTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDRLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSCDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKQNGMMEPDDFRACLISMGYDLGEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVASFKILAGDKNYITPEELRRELPAKQAEYCIRRMVPYKGSGAPAGALDYVAFSSALYGESDL
- Proteomes:
- UP000005640
Function
- Gene Ontology Go:
- brush border
Z disc
calcium ion binding
bone morphogenesis
muscle contraction
negative regulation of calcineurin-NFAT signaling cascade
negative regulation of glycolytic process
negative regulation of oxidative phosphorylation
negative regulation of relaxation of muscle
positive regulation of bone mineralization involved in bone maturation
positive regulation of fast-twitch skeletal muscle fiber contraction
positive regulation of glucose catabolic process to lactate via pyruvate
positive regulation of skeletal muscle fiber development
positive regulation of skeletal muscle tissue growth
regulation of aerobic respiration
regulation of the force of skeletal muscle contraction
response to denervation involved in regulation of muscle adaptation
skeletal muscle atrophy
transition between fast and slow fiber - Gene Ontology Biological Process:
- bone morphogenesis
muscle contraction
negative regulation of calcineurin-NFAT signaling cascade
negative regulation of glycolytic process
negative regulation of oxidative phosphorylation
negative regulation of relaxation of muscle
positive regulation of bone mineralization involved in bone maturation
positive regulation of fast-twitch skeletal muscle fiber contraction
positive regulation of glucose catabolic process to lactate via pyruvate
positive regulation of skeletal muscle fiber development
positive regulation of skeletal muscle tissue growth
regulation of aerobic respiration
regulation of the force of skeletal muscle contraction
response to denervation involved in regulation of muscle adaptation
skeletal muscle atrophy
transition between fast and slow fiber - Gene Ontology Molecular Function:
- calcium ion binding
- Gene Ontology Cellular Component:
- brush border
Z disc - Keywords:
- Actin-binding
Coiled coil
Complete proteome
Proteomics identification
Reference proteome
Repeat
Publication
- PubMed ID:
- 16554811