Names & Taxonomy
- Uniprot ID:
- O14979
- Entry Name:
- HNRDL_HUMAN
- Status:
- reviewed
- Protein Names:
- Heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like) (hnRNP DL) (AU-rich element RNA-binding factor) (JKT41-binding protein) (Protein laAUF1)
- Gene Names:
- HNRNPDL HNRPDL JKTBP
- Gene Names Primary:
- HNRNPDL
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 420
- Sequence:
- MEVPPRLSHVPPPLFPSAPATLASRSLSHWRPRPPRQLAPLLPSLAPSSARQGARRAQRHVTAQQPSRLAGGAAIKGGRRRRPDLFRRHFKSSSIQRSAAAAAATRTARQHPPADSSVTMEDMNEYSNIEEFAEGSKINASKNQQDDGKMFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAASVDKVLELKEHKLDGKLIDPKRAKALKGKEPPKKVFVGGLSPDTSEEQIKEYFGAFGEIENIELPMDTKTNERRGFCFITYTDEEPVKKLLESRYHQIGSGKCEIKVAQPKEVYRQQQQQQKGGRGAAAGGRGGTRGRGRGQGQNWNQGFNNYYDQGYGNYNSAYGGDQNYSGYGGYDYTGYNYGNYGYGQGYADYSGQQSTYGKASRGGGNHQNNYQPY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence.
- Gene Ontology Go:
- cytoplasm
extracellular exosome
nucleoplasm
nucleus
spliceosomal complex
DNA binding
double-stranded DNA binding
nucleotide binding
poly(A) binding
poly(A) RNA binding
poly(G) binding
single-stranded DNA binding
regulation of gene expression
regulation of transcription, DNA-templated
RNA processing
transcription, DNA-templated - Gene Ontology Biological Process:
- regulation of gene expression
regulation of transcription, DNA-templated
RNA processing
transcription, DNA-templated - Gene Ontology Molecular Function:
- DNA binding
double-stranded DNA binding
nucleotide binding
poly(A) binding
poly(A) RNA binding
poly(G) binding
single-stranded DNA binding - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome
nucleoplasm
nucleus
spliceosomal complex - Keywords:
- Acetylation
Activator
Alternative splicing
Complete proteome
Cytoplasm
DNA-binding
Direct protein sequencing
Disease mutation
Limb-girdle muscular dystrophy
Methylation
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
Repeat
Repressor
Transcription
Transcription regulation - Interacts With:
- Q15637