Names & Taxonomy

Uniprot ID:
O14979
Entry Name:
HNRDL_HUMAN
Status:
reviewed
Protein Names:
Heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like) (hnRNP DL) (AU-rich element RNA-binding factor) (JKT41-binding protein) (Protein laAUF1)
Gene Names:
HNRNPDL HNRPDL JKTBP
Gene Names Primary:
HNRNPDL
Organism:
Homo sapiens (Human)

Structure

Length:
420
Sequence:
MEVPPRLSHVPPPLFPSAPATLASRSLSHWRPRPPRQLAPLLPSLAPSSARQGARRAQRHVTAQQPSRLAGGAAIKGGRRRRPDLFRRHFKSSSIQRSAAAAAATRTARQHPPADSSVTMEDMNEYSNIEEFAEGSKINASKNQQDDGKMFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAASVDKVLELKEHKLDGKLIDPKRAKALKGKEPPKKVFVGGLSPDTSEEQIKEYFGAFGEIENIELPMDTKTNERRGFCFITYTDEEPVKKLLESRYHQIGSGKCEIKVAQPKEVYRQQQQQQKGGRGAAAGGRGGTRGRGRGQGQNWNQGFNNYYDQGYGNYNSAYGGDQNYSGYGGYDYTGYNYGNYGYGQGYADYSGQQSTYGKASRGGGNHQNNYQPY
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus

Function

Function:
Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence.
Gene Ontology Go:
cytoplasm
extracellular exosome
nucleoplasm
nucleus
spliceosomal complex
DNA binding
double-stranded DNA binding
nucleotide binding
poly(A) binding
poly(A) RNA binding
poly(G) binding
single-stranded DNA binding
regulation of gene expression
regulation of transcription, DNA-templated
RNA processing
transcription, DNA-templated
Gene Ontology Biological Process:
regulation of gene expression
regulation of transcription, DNA-templated
RNA processing
transcription, DNA-templated
Gene Ontology Molecular Function:
DNA binding
double-stranded DNA binding
nucleotide binding
poly(A) binding
poly(A) RNA binding
poly(G) binding
single-stranded DNA binding
Gene Ontology Cellular Component:
cytoplasm
extracellular exosome
nucleoplasm
nucleus
spliceosomal complex
Keywords:
Acetylation
Activator
Alternative splicing
Complete proteome
Cytoplasm
DNA-binding
Direct protein sequencing
Disease mutation
Limb-girdle muscular dystrophy
Methylation
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
Repeat
Repressor
Transcription
Transcription regulation
Interacts With:
Q15637

Publication

PubMed ID:
9538234 10072754 11705999 15815621 15489334 15190078 9524220 12406575 17081983 19413330 19690332 19608861 20068231 21269460 21406692 24647604 24275569