Names & Taxonomy
- Uniprot ID:
- O14975
- Entry Name:
- S27A2_HUMAN
- Status:
- reviewed
- Protein Names:
- Very long-chain acyl-CoA synthetase (VLACS) (VLCS) (EC 6.2.1.-) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 2) (THCA-CoA ligase) (Very long-chain-fatty-acid-CoA ligase)
- Gene Names:
- SLC27A2 ACSVL1 FACVL1 FATP2 VLACS
- Gene Names Primary:
- SLC27A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 620
- Sequence:
- MLSAIYTVLAGLLFLPLLVNLCCPYFFQDIGYFLKVAAVGRRVRSYGKRRPARTILRAFLEKARQTPHKPFLLFRDETLTYAQVDRRSNQVARALHDHLGLRQGDCVALLMGNEPAYVWLWLGLVKLGCAMACLNYNIRAKSLLHCFQCCGAKVLLVSPELQAAVEEILPSLKKDDVSIYYVSRTSNTDGIDSFLDKVDEVSTEPIPESWRSEVTFSTPALYIYTSGTTGLPKAAMITHQRIWYGTGLTFVSGLKADDVIYITLPFYHSAALLIGIHGCIVAGATLALRTKFSASQFWDDCRKYNVTVIQYIGELLRYLCNSPQKPNDRDHKVRLALGNGLRGDVWRQFVKRFGDICIYEFYAATEGNIGFMNYARKVGAVGRVNYLQKKIITYDLIKYDVEKDEPVRDENGYCVRVPKGEVGLLVCKITQLTPFNGYAGAKAQTEKKKLRDVFKKGDLYFNSGDLLMVDHENFIYFHDRVGDTFRWKGENVATTEVADTVGLVDFVQEVNVYGVHVPDHEGRIGMASIKMKENHEFDGKKLFQHIADYLPSYARPRFLRIQDTIEITGTFKHRKMTLVEEGFNPAVIKDALYFLDDTAKMYVPMTEDIYNAISAKTLKL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein. Note=Peripheral membrane associated with the lumenal side of peroxisomes.
Function
- Function:
- Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity).
- Catalytic Activity:
- ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
- Gene Ontology Go:
- endoplasmic reticulum lumen
endoplasmic reticulum membrane
extracellular exosome
integral component of endoplasmic reticulum membrane
integral component of peroxisomal membrane
mitochondrion
peroxisomal membrane
ATP binding
enzyme binding
fatty acid transporter activity
long-chain fatty acid-CoA ligase activity
phytanate-CoA ligase activity
pristanate-CoA ligase activity
receptor binding
very long-chain fatty acid-CoA ligase activity
bile acid biosynthetic process
bile acid metabolic process
cellular lipid metabolic process
fatty acid alpha-oxidation
fatty acid beta-oxidation
long-chain fatty acid import
long-chain fatty acid metabolic process
methyl-branched fatty acid metabolic process
small molecule metabolic process
very long-chain fatty acid catabolic process - Gene Ontology Biological Process:
- bile acid biosynthetic process
bile acid metabolic process
cellular lipid metabolic process
fatty acid alpha-oxidation
fatty acid beta-oxidation
long-chain fatty acid import
long-chain fatty acid metabolic process
methyl-branched fatty acid metabolic process
small molecule metabolic process
very long-chain fatty acid catabolic process - Gene Ontology Molecular Function:
- ATP binding
enzyme binding
fatty acid transporter activity
long-chain fatty acid-CoA ligase activity
phytanate-CoA ligase activity
pristanate-CoA ligase activity
receptor binding
very long-chain fatty acid-CoA ligase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum lumen
endoplasmic reticulum membrane
extracellular exosome
integral component of endoplasmic reticulum membrane
integral component of peroxisomal membrane
mitochondrion
peroxisomal membrane - Keywords:
- ATP-binding
Acetylation
Alternative splicing
Complete proteome
Endoplasmic reticulum
Fatty acid metabolism
Ligase
Lipid metabolism
Membrane
Nucleotide-binding
Peroxisome
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix