Names & Taxonomy

Uniprot ID:
O14939
Entry Name:
PLD2_HUMAN
Status:
reviewed
Protein Names:
Phospholipase D2 (PLD 2) (hPLD2) (EC 3.1.4.4) (Choline phosphatase 2) (PLD1C) (Phosphatidylcholine-hydrolyzing phospholipase D2)
Gene Names:
PLD2
Gene Names Primary:
PLD2
Organism:
Homo sapiens (Human)

Structure

Length:
933
Sequence:
MTATPESLFPTGDELDSSQLQMESDEVDTLKEGEDPADRMHPFLAIYELQSLKVHPLVFAPGVPVTAQVVGTERYTSGSKVGTCTLYSVRLTHGDFSWTTKKKYRHFQELHRDLLRHKVLMSLLPLARFAVAYSPARDAGNREMPSLPRAGPEGSTRHAASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGRKGLEGMIRKRSGGHRVPGLTCCGRDQVCYRWSKRWLVVKDSFLLYMCLETGAISFVQLFDPGFEVQVGKRSTEARHGVRIDTSHRSLILKCSSYRQARWWAQEITELAQGPGRDFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIFITDWWLSPEVYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRALMLLHPNIKVMRHPDQVTLWAHHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLTDLGDSSESAASQPPTPRPDSPATPDLSHNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPYLLPKSTSTANQLPFTLPGGQCTTVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDEIVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDYISICGLRTHGELGGHPVSELIYIHSKVLIADDRTVIIGSANINDRSLLGKRDSELAVLIEDTETEPSLMNGAEYQAGRFALSLRKHCFGVILGANTRPDLDLRDPICDDFFQLWQDMAESNANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARSELTQVQGHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
May have a role in signal-induced cytoskeletal regulation and/or endocytosis.
Catalytic Activity:
A phosphatidylcholine + H(2)O = choline + a phosphatidate.
Enzyme Regulation:
ENZYME REGULATION: Stimulated by phosphatidylinositol 4,5-bisphosphate and activated by the ADP-ribosylation factor-1 (ARF-1).
Cross Reference Drug Bank:
DB00122
Gene Ontology Go:
endoplasmic reticulum membrane
Golgi apparatus
plasma membrane
presynapse
N-acylphosphatidylethanolamine-specific phospholipase D activity
phosphatidylinositol binding
phospholipase D activity
cell motility
cytoskeleton organization
Fc-gamma receptor signaling pathway involved in phagocytosis
glycerophospholipid biosynthetic process
innate immune response
inositol lipid-mediated signaling
lipid catabolic process
phosphatidic acid biosynthetic process
phosphatidylglycerol biosynthetic process
phospholipid metabolic process
regulation of cell migration
regulation of phagocytosis
small GTPase mediated signal transduction
small molecule metabolic process
synaptic vesicle recycling
Gene Ontology Biological Process:
cell motility
cytoskeleton organization
Fc-gamma receptor signaling pathway involved in phagocytosis
glycerophospholipid biosynthetic process
innate immune response
inositol lipid-mediated signaling
lipid catabolic process
phosphatidic acid biosynthetic process
phosphatidylglycerol biosynthetic process
phospholipid metabolic process
regulation of cell migration
regulation of phagocytosis
small GTPase mediated signal transduction
small molecule metabolic process
synaptic vesicle recycling
Gene Ontology Molecular Function:
N-acylphosphatidylethanolamine-specific phospholipase D activity
phosphatidylinositol binding
phospholipase D activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
Golgi apparatus
plasma membrane
presynapse
Keywords:
Alternative splicing
Complete proteome
Hydrolase
Lipid degradation
Lipid metabolism
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Interacts With:
P23528; P62993

Publication

PubMed ID:
9761774 9582313 16625196 15489334 11032811 16959974