Names & Taxonomy
- Uniprot ID:
- O14939
- Entry Name:
- PLD2_HUMAN
- Status:
- reviewed
- Protein Names:
- Phospholipase D2 (PLD 2) (hPLD2) (EC 3.1.4.4) (Choline phosphatase 2) (PLD1C) (Phosphatidylcholine-hydrolyzing phospholipase D2)
- Gene Names:
- PLD2
- Gene Names Primary:
- PLD2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 933
- Sequence:
- MTATPESLFPTGDELDSSQLQMESDEVDTLKEGEDPADRMHPFLAIYELQSLKVHPLVFAPGVPVTAQVVGTERYTSGSKVGTCTLYSVRLTHGDFSWTTKKKYRHFQELHRDLLRHKVLMSLLPLARFAVAYSPARDAGNREMPSLPRAGPEGSTRHAASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGRKGLEGMIRKRSGGHRVPGLTCCGRDQVCYRWSKRWLVVKDSFLLYMCLETGAISFVQLFDPGFEVQVGKRSTEARHGVRIDTSHRSLILKCSSYRQARWWAQEITELAQGPGRDFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIFITDWWLSPEVYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRALMLLHPNIKVMRHPDQVTLWAHHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLTDLGDSSESAASQPPTPRPDSPATPDLSHNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPYLLPKSTSTANQLPFTLPGGQCTTVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDEIVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDYISICGLRTHGELGGHPVSELIYIHSKVLIADDRTVIIGSANINDRSLLGKRDSELAVLIEDTETEPSLMNGAEYQAGRFALSLRKHCFGVILGANTRPDLDLRDPICDDFFQLWQDMAESNANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARSELTQVQGHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- May have a role in signal-induced cytoskeletal regulation and/or endocytosis.
- Catalytic Activity:
- A phosphatidylcholine + H(2)O = choline + a phosphatidate.
- Enzyme Regulation:
- ENZYME REGULATION: Stimulated by phosphatidylinositol 4,5-bisphosphate and activated by the ADP-ribosylation factor-1 (ARF-1).
- Cross Reference Drug Bank:
- DB00122
- Gene Ontology Go:
- endoplasmic reticulum membrane
Golgi apparatus
plasma membrane
presynapse
N-acylphosphatidylethanolamine-specific phospholipase D activity
phosphatidylinositol binding
phospholipase D activity
cell motility
cytoskeleton organization
Fc-gamma receptor signaling pathway involved in phagocytosis
glycerophospholipid biosynthetic process
innate immune response
inositol lipid-mediated signaling
lipid catabolic process
phosphatidic acid biosynthetic process
phosphatidylglycerol biosynthetic process
phospholipid metabolic process
regulation of cell migration
regulation of phagocytosis
small GTPase mediated signal transduction
small molecule metabolic process
synaptic vesicle recycling - Gene Ontology Biological Process:
- cell motility
cytoskeleton organization
Fc-gamma receptor signaling pathway involved in phagocytosis
glycerophospholipid biosynthetic process
innate immune response
inositol lipid-mediated signaling
lipid catabolic process
phosphatidic acid biosynthetic process
phosphatidylglycerol biosynthetic process
phospholipid metabolic process
regulation of cell migration
regulation of phagocytosis
small GTPase mediated signal transduction
small molecule metabolic process
synaptic vesicle recycling - Gene Ontology Molecular Function:
- N-acylphosphatidylethanolamine-specific phospholipase D activity
phosphatidylinositol binding
phospholipase D activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
Golgi apparatus
plasma membrane
presynapse - Keywords:
- Alternative splicing
Complete proteome
Hydrolase
Lipid degradation
Lipid metabolism
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat - Interacts With:
- P23528; P62993