Names & Taxonomy

Uniprot ID:
O14732
Entry Name:
IMPA2_HUMAN
Status:
reviewed
Protein Names:
Inositol monophosphatase 2 (IMP 2) (IMPase 2) (EC 3.1.3.25) (Inositol-1(or 4)-monophosphatase 2) (Myo-inositol monophosphatase A2)
Gene Names:
IMPA2 IMP.18P
Gene Names Primary:
IMPA2
Organism:
Homo sapiens (Human)

Structure

Length:
288
Sequence:
MKPSGEDQAALAAGPWEECFQAAVQLALRAGQIIRKALTEEKRVSTKTSAADLVTETDHLVEDLIISELRERFPSHRFIAEEAAASGAKCVLTHSPTWIIDPIDGTCNFVHRFPTVAVSIGFAVRQELEFGVIYHCTEERLYTGRRGRGAFCNGQRLRVSGETDLSKALVLTEIGPKRDPATLKLFLSNMERLLHAKAHGVRVIGSSTLALCHLASGAADAYYQFGLHCWDLAAATVIIREAGGIVIDTSGGPLDLMACRVVAASTREMAMLIAQALQTINYGRDDEK
Proteomes:
UP000005640

Function

Function:
Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.
Pathway:
Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.
Catalytic Activity:
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=5 mM for myo-inositol 1-monophosphate
Enzyme Regulation:
ENZYME REGULATION: Inhibited by high Li(+) and restricted Mg(2+) concentrations.
Cross Reference Drug Bank:
DB01356
Gene Ontology Go:
cytoplasm
cytosol
inositol monophosphate 1-phosphatase activity
inositol monophosphate 3-phosphatase activity
inositol monophosphate 4-phosphatase activity
magnesium ion binding
protein homodimerization activity
inositol biosynthetic process
inositol metabolic process
inositol phosphate dephosphorylation
inositol phosphate metabolic process
phosphate-containing compound metabolic process
phosphatidylinositol phosphorylation
signal transduction
small molecule metabolic process
Gene Ontology Biological Process:
inositol biosynthetic process
inositol metabolic process
inositol phosphate dephosphorylation
inositol phosphate metabolic process
phosphate-containing compound metabolic process
phosphatidylinositol phosphorylation
signal transduction
small molecule metabolic process
Gene Ontology Molecular Function:
inositol monophosphate 1-phosphatase activity
inositol monophosphate 3-phosphatase activity
inositol monophosphate 4-phosphatase activity
magnesium ion binding
protein homodimerization activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
Keywords:
3D-structure
Alternative splicing
Complete proteome
Hydrolase
Magnesium
Metal-binding
Polymorphism
Reference proteome
Interacts With:
P29218; Q8TBC4

Publication

PubMed ID:
9322233 10822345 15489334 15504365 17068342 21269460 17340635