Names & Taxonomy
- Uniprot ID:
- O14732
- Entry Name:
- IMPA2_HUMAN
- Status:
- reviewed
- Protein Names:
- Inositol monophosphatase 2 (IMP 2) (IMPase 2) (EC 3.1.3.25) (Inositol-1(or 4)-monophosphatase 2) (Myo-inositol monophosphatase A2)
- Gene Names:
- IMPA2 IMP.18P
- Gene Names Primary:
- IMPA2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 288
- Sequence:
- MKPSGEDQAALAAGPWEECFQAAVQLALRAGQIIRKALTEEKRVSTKTSAADLVTETDHLVEDLIISELRERFPSHRFIAEEAAASGAKCVLTHSPTWIIDPIDGTCNFVHRFPTVAVSIGFAVRQELEFGVIYHCTEERLYTGRRGRGAFCNGQRLRVSGETDLSKALVLTEIGPKRDPATLKLFLSNMERLLHAKAHGVRVIGSSTLALCHLASGAADAYYQFGLHCWDLAAATVIIREAGGIVIDTSGGPLDLMACRVVAASTREMAMLIAQALQTINYGRDDEK
- Proteomes:
- UP000005640
Function
- Function:
- Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.
- Pathway:
- Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.
- Catalytic Activity:
- Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=5 mM for myo-inositol 1-monophosphate
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by high Li(+) and restricted Mg(2+) concentrations.
- Cross Reference Drug Bank:
- DB01356
- Gene Ontology Go:
- cytoplasm
cytosol
inositol monophosphate 1-phosphatase activity
inositol monophosphate 3-phosphatase activity
inositol monophosphate 4-phosphatase activity
magnesium ion binding
protein homodimerization activity
inositol biosynthetic process
inositol metabolic process
inositol phosphate dephosphorylation
inositol phosphate metabolic process
phosphate-containing compound metabolic process
phosphatidylinositol phosphorylation
signal transduction
small molecule metabolic process - Gene Ontology Biological Process:
- inositol biosynthetic process
inositol metabolic process
inositol phosphate dephosphorylation
inositol phosphate metabolic process
phosphate-containing compound metabolic process
phosphatidylinositol phosphorylation
signal transduction
small molecule metabolic process - Gene Ontology Molecular Function:
- inositol monophosphate 1-phosphatase activity
inositol monophosphate 3-phosphatase activity
inositol monophosphate 4-phosphatase activity
magnesium ion binding
protein homodimerization activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Hydrolase
Magnesium
Metal-binding
Polymorphism
Reference proteome - Interacts With:
- P29218; Q8TBC4