Names & Taxonomy
- Uniprot ID:
- O14594
- Entry Name:
- NCAN_HUMAN
- Status:
- reviewed
- Protein Names:
- Neurocan core protein (Chondroitin sulfate proteoglycan 3)
- Gene Names:
- NCAN CSPG3 NEUR
- Gene Names Primary:
- NCAN
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1321
- Sequence:
- MGAPFVWALGLLMLQMLLFVAGEQGTQDITDASERGLHMQKLGSGSVQAALAELVALPCLFTLQPRPSAARDAPRIKWTKVRTASGQRQDLPILVAKDNVVRVAKSWQGRVSLPSYPRRRANATLLLGPLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVVFHYRSARDRYALTFAEAQEACRLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRYPITQSRPGCYGDRSSLPGVRSYGRRNPQELYDVYCFARELGGEVFYVGPARRLTLAGARAQCRRQGAALASVGQLHLAWHEGLDQCDPGWLADGSVRYPIQTPRRRCGGPAPGVRTVYRFANRTGFPSPAERFDAYCFRAHHPTSQHGDLETPSSGDEGEILSAEGPPVRELEPTLEEEEVVTPDFQEPLVSSGEEETLILEEKQESQQTLSPTPGDPMLASWPTGEVWLSTVAPSPSDMGAGTAASSHTEVAPTDPMPRRRGRFKGLNGRYFQQQEPEPGLQGGMEASAQPPTSEAAVNQMEPPLAMAVTEMLGSGQSRSPWADLTNEVDMPGAGSAGGKSSPEPWLWPPTMVPPSISGHSRAPVLELEKAEGPSARPATPDLFWSPLEATVSAPSPAPWEAFPVATSPDLPMMAMLRGPKEWMLPHPTPISTEANRVEAHGEATATAPPSPAAETKVYSLPLSLTPTGQGGEAMPTTPESPRADFRETGETSPAQVNKAEHSSSSPWPSVNRNVAVGFVPTETATEPTGLRGIPGSESGVFDTAESPTSGLQATVDEVQDPWPSVYSKGLDASSPSAPLGSPGVFLVPKVTPNLEPWVATDEGPTVNPMDSTVTPAPSDASGIWEPGSQVFEEAESTTLSPQVALDTSIVTPLTTLEQGDKVGVPAMSTLGSSSSQPHPEPEDQVETQGTSGASVPPHQSSPLGKPAVPPGTPTAASVGESASVSSGEPTVPWDPSSTLLPVTLGIEDFELEVLAGSPGVESFWEEVASGEEPALPGTPMNAGAEEVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINSFGHENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPCNYNLPYVCKKGTVLCGPPPAVENASLIGARKAKYNVHATVRYQCNEGFAQHHVATIRCRSNGKWDRPQIVCTKPRRSHRMRRHHHHHQHHHQHHHHKSRKERRKHKKHPTEDWEKDEGNFC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
- Cross Reference Drug Bank:
- DB08818
- Gene Ontology Go:
- extracellular region
Golgi lumen
lysosomal lumen
proteinaceous extracellular matrix
calcium ion binding
carbohydrate binding
hyaluronic acid binding
axon guidance
carbohydrate metabolic process
cell adhesion
central nervous system development
chondroitin sulfate biosynthetic process
chondroitin sulfate catabolic process
chondroitin sulfate metabolic process
dermatan sulfate biosynthetic process
extracellular matrix organization
glycosaminoglycan metabolic process
skeletal system development
small molecule metabolic process - Gene Ontology Biological Process:
- axon guidance
carbohydrate metabolic process
cell adhesion
central nervous system development
chondroitin sulfate biosynthetic process
chondroitin sulfate catabolic process
chondroitin sulfate metabolic process
dermatan sulfate biosynthetic process
extracellular matrix organization
glycosaminoglycan metabolic process
skeletal system development
small molecule metabolic process - Gene Ontology Molecular Function:
- calcium ion binding
carbohydrate binding
hyaluronic acid binding - Gene Ontology Cellular Component:
- extracellular region
Golgi lumen
lysosomal lumen
proteinaceous extracellular matrix - Keywords:
- Calcium
Cell adhesion
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Hyaluronic acid
Immunoglobulin domain
Lectin
Polymorphism
Proteoglycan
Reference proteome
Repeat
Secreted
Signal
Sushi