Names & Taxonomy
- Uniprot ID:
- O00764
- Entry Name:
- PDXK_HUMAN
- Status:
- reviewed
- Protein Names:
- Pyridoxal kinase (EC 2.7.1.35) (Pyridoxine kinase)
- Gene Names:
- PDXK C21orf124 C21orf97 PKH PNK PRED79
- Gene Names Orf:
- PRED79
- Gene Names Primary:
- PDXK
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 312
- Sequence:
- MEEECRVLSIQSHVIRGYVGNRAATFPLQVLGFEIDAVNSVQFSNHTGYAHWKGQVLNSDELQELYEGLRLNNMNKYDYVLTGYTRDKSFLAMVVDIVQELKQQNPRLVYVCDPVLGDKWDGEGSMYVPEDLLPVYKEKVVPLADIITPNQFEAELLSGRKIHSQEEALRVMDMLHSMGPDTVVITSSDLPSPQGSNYLIVLGSQRRRNPAGSVVMERIRMDIRKVDAVFVGTGDLFAAMLLAWTHKHPNNLKVACEKTVSTLHHVLQRTIQCAKAQAGEGVRPSPMQLELRMVQSKRDIEDPEIVVQATVL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
- Catalytic Activity:
- ATP + pyridoxal = ADP + pyridoxal 5'-phosphate.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; ; Note=Divalent metal cations. Zn(2+) is more efficient than Mg(2+).;
- Cross Reference Drug Bank:
- DB00147 DB00165
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
nucleoplasm
nucleus
ATP binding
lithium ion binding
magnesium ion binding
potassium ion binding
protein homodimerization activity
pyridoxal kinase activity
pyridoxal phosphate binding
sodium ion binding
zinc ion binding
cell proliferation
pyridoxal 5'-phosphate salvage
pyridoxal phosphate biosynthetic process
small molecule metabolic process
vitamin B6 metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- cell proliferation
pyridoxal 5'-phosphate salvage
pyridoxal phosphate biosynthetic process
small molecule metabolic process
vitamin B6 metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- ATP binding
lithium ion binding
magnesium ion binding
potassium ion binding
protein homodimerization activity
pyridoxal kinase activity
pyridoxal phosphate binding
sodium ion binding
zinc ion binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
nucleoplasm
nucleus - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Kinase
Metal-binding
Nucleotide-binding
Phosphoprotein
Reference proteome
Transferase
Zinc