Names & Taxonomy
- Uniprot ID:
- O00459
- Entry Name:
- P85B_HUMAN
- Status:
- reviewed
- Protein Names:
- Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
- Gene Names:
- PIK3R2
- Gene Names Primary:
- PIK3R2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 728
- Sequence:
- MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
- Proteomes:
- UP000005640
Function
- Function:
- Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).
- Cross Reference Drug Bank:
- DB01064
- Gene Ontology Go:
- cytosol
nucleus
phosphatidylinositol 3-kinase complex
1-phosphatidylinositol-3-kinase regulator activity
protein heterodimerization activity
protein phosphatase binding
receptor tyrosine kinase binding
blood coagulation
cellular glucose homeostasis
cellular response to insulin stimulus
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
leukocyte migration
neurotrophin TRK receptor signaling pathway
phosphatidylinositol 3-kinase signaling
phosphatidylinositol biosynthetic process
phosphatidylinositol phosphorylation
phosphatidylinositol-3-phosphate biosynthetic process
phosphatidylinositol-mediated signaling
phospholipid metabolic process
positive regulation of glucose import in response to insulin stimulus
positive regulation of transcription factor import into nucleus
positive regulation of transcription from RNA polymerase II promoter
protein transport
regulation of autophagy
regulation of phosphatidylinositol 3-kinase activity
regulation of small GTPase mediated signal transduction
response to endoplasmic reticulum stress
small GTPase mediated signal transduction
small molecule metabolic process
T cell receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- blood coagulation
cellular glucose homeostasis
cellular response to insulin stimulus
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
leukocyte migration
neurotrophin TRK receptor signaling pathway
phosphatidylinositol 3-kinase signaling
phosphatidylinositol-3-phosphate biosynthetic process
phosphatidylinositol biosynthetic process
phosphatidylinositol-mediated signaling
phosphatidylinositol phosphorylation
phospholipid metabolic process
positive regulation of glucose import in response to insulin stimulus
positive regulation of transcription factor import into nucleus
positive regulation of transcription from RNA polymerase II promoter
protein transport
regulation of autophagy
regulation of phosphatidylinositol 3-kinase activity
regulation of small GTPase mediated signal transduction
response to endoplasmic reticulum stress
small GTPase mediated signal transduction
small molecule metabolic process
T cell receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- 1-phosphatidylinositol-3-kinase regulator activity
protein heterodimerization activity
protein phosphatase binding
receptor tyrosine kinase binding - Gene Ontology Cellular Component:
- cytosol
nucleus
phosphatidylinositol 3-kinase complex - Keywords:
- 3D-structure
Complete proteome
Disease mutation
Phosphoprotein
Polymorphism
Protein transport
Reference proteome
Repeat
SH2 domain
SH3 domain
Stress response
Transport
Ubl conjugation - Interacts With:
- P10275; P22681; Q8WWB3; P00533; P04626; P21860; Q13480; Q08379; P62993; P42858; Q9UKT9; P10721; P19012; P35900; O76015; P08581; Q96HT8; P03496; P42338; Q6NUQ1; P36406