Names & Taxonomy
- Uniprot ID:
- O00329
- Entry Name:
- PK3CD_HUMAN
- Status:
- reviewed
- Protein Names:
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta)
- Gene Names:
- PIK3CD
- Gene Names Primary:
- PIK3CD
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1044
- Sequence:
- MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity.
- Pathway:
- Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.
- Catalytic Activity:
- ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
- Enzyme Regulation:
- ENZYME REGULATION: Activated by growth factors and cytokine receptors through a tyrosine-kinase-dependent mechanism. Activated by RAS. IC87114 inhibits lipid kinase activity and is selective in cells at doses up to 5-10 uM. IC87114 blocks T-cell receptor signaling in naive and memory T-cells and reduces cytokine production by memory T-cells.
- Cross Reference Drug Bank:
- DB00201
- Gene Ontology Go:
- cytosol
mast cell granule
phosphatidylinositol 3-kinase complex
plasma membrane
1-phosphatidylinositol-3-kinase activity
1-phosphatidylinositol-4-phosphate 3-kinase activity
ATP binding
phosphatidylinositol 3-kinase activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
adaptive immune response
B cell activation
B cell chemotaxis
B cell receptor signaling pathway
cytokine production
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
inflammatory response
innate immune response
mast cell chemotaxis
mast cell degranulation
mast cell differentiation
natural killer cell activation
natural killer cell chemotaxis
natural killer cell differentiation
neurotrophin TRK receptor signaling pathway
neutrophil chemotaxis
neutrophil extravasation
phosphatidylinositol 3-kinase signaling
phosphatidylinositol biosynthetic process
phosphatidylinositol-3-phosphate biosynthetic process
phosphatidylinositol-mediated signaling
phospholipid metabolic process
platelet activation
positive regulation of cell migration
positive regulation of gene expression
protein phosphorylation
respiratory burst involved in defense response
signal transduction
small molecule metabolic process
T cell activation
T cell chemotaxis
T cell differentiation
T cell receptor signaling pathway - Gene Ontology Biological Process:
- adaptive immune response
B cell activation
B cell chemotaxis
B cell receptor signaling pathway
cytokine production
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
inflammatory response
innate immune response
mast cell chemotaxis
mast cell degranulation
mast cell differentiation
natural killer cell activation
natural killer cell chemotaxis
natural killer cell differentiation
neurotrophin TRK receptor signaling pathway
neutrophil chemotaxis
neutrophil extravasation
phosphatidylinositol 3-kinase signaling
phosphatidylinositol-3-phosphate biosynthetic process
phosphatidylinositol biosynthetic process
phosphatidylinositol-mediated signaling
phospholipid metabolic process
platelet activation
positive regulation of cell migration
positive regulation of gene expression
protein phosphorylation
respiratory burst involved in defense response
signal transduction
small molecule metabolic process
T cell activation
T cell chemotaxis
T cell differentiation
T cell receptor signaling pathway - Gene Ontology Molecular Function:
- 1-phosphatidylinositol-3-kinase activity
1-phosphatidylinositol-4-phosphate 3-kinase activity
ATP binding
phosphatidylinositol 3-kinase activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity - Gene Ontology Cellular Component:
- cytosol
mast cell granule
phosphatidylinositol 3-kinase complex
plasma membrane - Keywords:
- 3D-structure
ATP-binding
Adaptive immunity
Alternative splicing
Chemotaxis
Complete proteome
Cytoplasm
Differentiation
Direct protein sequencing
Disease mutation
Immunity
Inflammatory response
Innate immunity
Kinase
Nucleotide-binding
Phosphoprotein
Reference proteome
Transferase - Interacts With:
- P01112