Names & Taxonomy

Uniprot ID:
L7RTI5
Entry Name:
L7RTI5_HUMAN
Status:
unreviewed
Protein Names:
Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon)
Gene Names:
PRKCE
Gene Names Primary:
PRKCE
Organism:
Homo sapiens (Human)

Structure

Length:
737
Sequence:
MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLMP

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.
Catalytic Activity:
ATP + a protein = ADP + a phosphoprotein.
Enzyme Regulation:
ENZYME REGULATION: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
Gene Ontology Go:
cytoskeleton
cytosol
Golgi apparatus
mitochondrion
nucleus
perinuclear region of cytoplasm
plasma membrane
ATP binding
calcium-independent protein kinase C activity
ethanol binding
metal ion binding
receptor activator activity
cell adhesion
cell cycle
cell division
cellular response to ethanol
cellular response to hypoxia
cellular response to prostaglandin E stimulus
intracellular signal transduction
lipopolysaccharide-mediated signaling pathway
locomotory exploration behavior
macrophage activation involved in immune response
negative regulation of protein ubiquitination
positive regulation of actin filament polymerization
positive regulation of cell-substrate adhesion
positive regulation of fibroblast migration
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of insulin secretion
positive regulation of lipid catabolic process
positive regulation of MAPK cascade
positive regulation of mucus secretion
positive regulation of synaptic transmission, GABAergic
regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of peptidyl-tyrosine phosphorylation
regulation of release of sequestered calcium ion into cytosol
release of sequestered calcium ion into cytosol
response to morphine
TRAM-dependent toll-like receptor 4 signaling pathway
Gene Ontology Biological Process:
cell adhesion
cell cycle
cell division
cellular response to ethanol
cellular response to hypoxia
cellular response to prostaglandin E stimulus
intracellular signal transduction
lipopolysaccharide-mediated signaling pathway
locomotory exploration behavior
macrophage activation involved in immune response
negative regulation of protein ubiquitination
positive regulation of actin filament polymerization
positive regulation of cell-substrate adhesion
positive regulation of fibroblast migration
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of insulin secretion
positive regulation of lipid catabolic process
positive regulation of MAPK cascade
positive regulation of mucus secretion
positive regulation of synaptic transmission, GABAergic
regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of peptidyl-tyrosine phosphorylation
regulation of release of sequestered calcium ion into cytosol
release of sequestered calcium ion into cytosol
response to morphine
TRAM-dependent toll-like receptor 4 signaling pathway
Gene Ontology Molecular Function:
ATP binding
calcium-independent protein kinase C activity
ethanol binding
metal ion binding
receptor activator activity
Gene Ontology Cellular Component:
cytoskeleton
cytosol
Golgi apparatus
mitochondrion
nucleus
perinuclear region of cytoplasm
plasma membrane
Keywords:
ATP-binding
Cell adhesion
Cell cycle
Cell division
Cell membrane
Cytoplasm
Cytoskeleton
Kinase
Membrane
Metal-binding
Nucleotide-binding
Nucleus
Serine/threonine-protein kinase
Transferase
Zinc
Zinc-finger