Names & Taxonomy
- Uniprot ID:
- L7RSL3
- Entry Name:
- L7RSL3_HUMAN
- Status:
- unreviewed
- Protein Names:
- Fms-related tyrosine kinase 1 (Vascular endothelial growth factor/vascular permeability factor receptor)
- Gene Names:
- FLT1
- Gene Names Primary:
- FLT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1338
- Sequence:
- MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFIRKMKRSSSEIKTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQDGKDYIPINAILTGNSGFTYSTPAFSEDFFKESISAPKFNSGSSDDVRYVNAFKFMSLERIKTFEELLPNATSMFDDYQGDSSTLLASPMLKRFTWTDSKPKASLKIDLRVTSKSKESGLSDVSRPSFCHSSCGHVSEGKRRFTYDHAELERKIACCSPPPDYNSVVLYSTPPI
Subcellular location
- Subcellular Location:
- Membrane
Function
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Gene Ontology Go:
- integral component of plasma membrane
ATP binding
vascular endothelial growth factor-activated receptor activity
activation of MAPKK activity
intracellular receptor signaling pathway
positive regulation of cell migration
positive regulation of smooth muscle cell proliferation
regulation of smooth muscle contraction
response to hypoxia
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- activation of MAPKK activity
intracellular receptor signaling pathway
positive regulation of cell migration
positive regulation of smooth muscle cell proliferation
regulation of smooth muscle contraction
response to hypoxia
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- ATP binding
vascular endothelial growth factor-activated receptor activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
- Keywords:
- ATP-binding
Disulfide bond
Immunoglobulin domain
Kinase
Membrane
Nucleotide-binding
Phosphoprotein
Receptor
Repeat
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase