Names & Taxonomy

Uniprot ID:
L7RSL3
Entry Name:
L7RSL3_HUMAN
Status:
unreviewed
Protein Names:
Fms-related tyrosine kinase 1 (Vascular endothelial growth factor/vascular permeability factor receptor)
Gene Names:
FLT1
Gene Names Primary:
FLT1
Organism:
Homo sapiens (Human)

Structure

Length:
1338
Sequence:
MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFIRKMKRSSSEIKTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQDGKDYIPINAILTGNSGFTYSTPAFSEDFFKESISAPKFNSGSSDDVRYVNAFKFMSLERIKTFEELLPNATSMFDDYQGDSSTLLASPMLKRFTWTDSKPKASLKIDLRVTSKSKESGLSDVSRPSFCHSSCGHVSEGKRRFTYDHAELERKIACCSPPPDYNSVVLYSTPPI

Subcellular location

Subcellular Location:
Membrane

Function

Catalytic Activity:
ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
Gene Ontology Go:
integral component of plasma membrane
ATP binding
vascular endothelial growth factor-activated receptor activity
activation of MAPKK activity
intracellular receptor signaling pathway
positive regulation of cell migration
positive regulation of smooth muscle cell proliferation
regulation of smooth muscle contraction
response to hypoxia
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Biological Process:
activation of MAPKK activity
intracellular receptor signaling pathway
positive regulation of cell migration
positive regulation of smooth muscle cell proliferation
regulation of smooth muscle contraction
response to hypoxia
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Molecular Function:
ATP binding
vascular endothelial growth factor-activated receptor activity
Gene Ontology Cellular Component:
integral component of plasma membrane
Keywords:
ATP-binding
Disulfide bond
Immunoglobulin domain
Kinase
Membrane
Nucleotide-binding
Phosphoprotein
Receptor
Repeat
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase