Names & Taxonomy

Uniprot ID:
H7C276
Entry Name:
H7C276_HUMAN
Status:
unreviewed
Protein Names:
Phosphoinositide phospholipase C (EC 3.1.4.11) (Fragment)
Gene Names:
PLCL2
Gene Names Primary:
PLCL2
Organism:
Homo sapiens (Human)

Structure

Length:
704
Sequence:
XIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKIRKTGRRSIFVPQTPIMV
Proteomes:
UP000005640

Function

Catalytic Activity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Gene Ontology Go:
intracellular
phosphatidylinositol phospholipase C activity
signal transducer activity
intracellular signal transduction
lipid catabolic process
Gene Ontology Biological Process:
intracellular signal transduction
lipid catabolic process
Gene Ontology Molecular Function:
phosphatidylinositol phospholipase C activity
signal transducer activity
Gene Ontology Cellular Component:
intracellular
Keywords:
Complete proteome
Hydrolase
Lipid degradation
Lipid metabolism
Proteomics identification
Reference proteome
Transducer

Publication

PubMed ID:
16641997 18669648 19413330 19690332 24275569