Names & Taxonomy
- Uniprot ID:
- H0YIZ0
- Entry Name:
- H0YIZ0_HUMAN
- Status:
- unreviewed
- Protein Names:
- Serine hydroxymethyltransferase (EC 2.1.2.1) (Fragment)
- Gene Names:
- SHMT2
- Gene Names Primary:
- SHMT2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 264
- Sequence:
- XGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTGE
- Proteomes:
- UP000005640
Function
- Function:
- Interconversion of serine and glycine.
- Pathway:
- One-carbon metabolism; tetrahydrofolate interconversion.
- Catalytic Activity:
- 5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Gene Ontology Go:
- glycine hydroxymethyltransferase activity
pyridoxal phosphate binding
glycine metabolic process
L-serine metabolic process
tetrahydrofolate interconversion - Gene Ontology Biological Process:
- glycine metabolic process
L-serine metabolic process
tetrahydrofolate interconversion - Gene Ontology Molecular Function:
- glycine hydroxymethyltransferase activity
pyridoxal phosphate binding - Keywords:
- Complete proteome
One-carbon metabolism
Proteomics identification
Pyridoxal phosphate
Reference proteome
Transferase