Names & Taxonomy
- Uniprot ID:
- A0A023I8C2
- Entry Name:
- A0A023I8C2_HUMAN
- Status:
- unreviewed
- Protein Names:
- Cytochrome c oxidase subunit 1 (EC 1.9.3.1)
- Gene Names:
- COX1
- Gene Names Primary:
- COX1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 513
- Sequence:
- MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVNLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKS
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane
- Gene Encoded:
- Mitochondrion
Function
- Function:
- Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
- Pathway:
- Energy metabolism; oxidative phosphorylation.
- Catalytic Activity:
- 4 ferrocytochrome c + O(2) + 4 H(+) = 4 ferricytochrome c + 2 H(2)O.
- Gene Ontology Go:
- integral component of membrane
mitochondrial inner membrane
respiratory chain
cytochrome-c oxidase activity
heme binding
iron ion binding
aerobic respiration
oxidative phosphorylation - Gene Ontology Biological Process:
- aerobic respiration
oxidative phosphorylation - Gene Ontology Molecular Function:
- cytochrome-c oxidase activity
heme binding
iron ion binding - Gene Ontology Cellular Component:
- integral component of membrane
mitochondrial inner membrane
respiratory chain - Keywords:
- Copper
Electron transport
Heme
Iron
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Oxidoreductase
Respiratory chain
Transmembrane
Transmembrane helix
Transport