Names & Taxonomy
- Uniprot ID:
- D3DRD3
- Entry Name:
- D3DRD3_HUMAN
- Status:
- unreviewed
- Protein Names:
- Fibroblast growth factor receptor (EC 2.7.10.1)
- Gene Names:
- FGFR2 hCG_1811153
- Gene Names Orf:
- hCG_1811153
- Gene Names Primary:
- FGFR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 724
- Sequence:
- MGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
Function
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Active Site:
- ACT_SITE 529 529 Proton acceptor.
- Gene Ontology Go:
- integral component of membrane
ATP binding
fibroblast growth factor-activated receptor activity
positive regulation of cell proliferation - Gene Ontology Biological Process:
- positive regulation of cell proliferation
- Gene Ontology Molecular Function:
- ATP binding
fibroblast growth factor-activated receptor activity - Gene Ontology Cellular Component:
- integral component of membrane
- Keywords:
- ATP-binding
Disulfide bond
Immunoglobulin domain
Kinase
Membrane
Nucleotide-binding
Receptor
Repeat
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase
Publication
- PubMed ID:
- 11181995