Names & Taxonomy
- Uniprot ID:
- A0A024RDA0
- Entry Name:
- A0A024RDA0_HUMAN
- Status:
- unreviewed
- Protein Names:
- V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, isoform CRA_a
- Gene Names:
- KIT hCG_22160
- Gene Names Orf:
- hCG_22160
- Gene Names Primary:
- KIT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 976
- Sequence:
- MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV
Subcellular location
- Subcellular Location:
- Membrane
Function
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Active Site:
- ACT_SITE 792 792 Proton acceptor.
- Gene Ontology Go:
- acrosomal vesicle
cell-cell junction
cytoplasmic side of plasma membrane
external side of plasma membrane
integral component of membrane
ATP binding
receptor signaling protein tyrosine kinase activity
stem cell factor receptor activity
cellular response to thyroid hormone stimulus
dendritic cell cytokine production
detection of mechanical stimulus involved in sensory perception of sound
digestive tract development
ectopic germ cell programmed cell death
embryonic hemopoiesis
epithelial cell proliferation
erythrocyte differentiation
erythropoietin-mediated signaling pathway
Fc receptor signaling pathway
germ cell migration
glycosphingolipid metabolic process
hematopoietic stem cell migration
immature B cell differentiation
inflammatory response
intracellular signal transduction
lamellipodium assembly
lymphoid progenitor cell differentiation
mast cell differentiation
megakaryocyte development
melanocyte adhesion
melanocyte differentiation
melanocyte migration
myeloid progenitor cell differentiation
negative regulation of programmed cell death
ovarian follicle development
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of long-term neuronal synaptic plasticity
positive regulation of MAP kinase activity
positive regulation of Notch signaling pathway
positive regulation of pseudopodium assembly
protein autophosphorylation
regulation of cell shape
regulation of developmental pigmentation
somatic stem cell division
somatic stem cell population maintenance
spermatid development
stem cell differentiation
T cell differentiation
visual learning - Gene Ontology Biological Process:
- cellular response to thyroid hormone stimulus
dendritic cell cytokine production
detection of mechanical stimulus involved in sensory perception of sound
digestive tract development
ectopic germ cell programmed cell death
embryonic hemopoiesis
epithelial cell proliferation
erythrocyte differentiation
erythropoietin-mediated signaling pathway
Fc receptor signaling pathway
germ cell migration
glycosphingolipid metabolic process
hematopoietic stem cell migration
immature B cell differentiation
inflammatory response
intracellular signal transduction
lamellipodium assembly
lymphoid progenitor cell differentiation
mast cell differentiation
megakaryocyte development
melanocyte adhesion
melanocyte differentiation
melanocyte migration
myeloid progenitor cell differentiation
negative regulation of programmed cell death
ovarian follicle development
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of long-term neuronal synaptic plasticity
positive regulation of MAP kinase activity
positive regulation of Notch signaling pathway
positive regulation of pseudopodium assembly
protein autophosphorylation
regulation of cell shape
regulation of developmental pigmentation
somatic stem cell division
somatic stem cell population maintenance
spermatid development
stem cell differentiation
T cell differentiation
visual learning - Gene Ontology Molecular Function:
- ATP binding
receptor signaling protein tyrosine kinase activity
stem cell factor receptor activity - Gene Ontology Cellular Component:
- acrosomal vesicle
cell-cell junction
cytoplasmic side of plasma membrane
external side of plasma membrane
integral component of membrane - Keywords:
- ATP-binding
Disulfide bond
Immunoglobulin domain
Kinase
Membrane
Nucleotide-binding
Phosphoprotein
Receptor
Repeat
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase
Publication
- PubMed ID:
- 11181995