Names & Taxonomy

Uniprot ID:
A0A024RC42
Entry Name:
A0A024RC42_HUMAN
Status:
unreviewed
Protein Names:
Cadherin 2, type 1, N-cadherin (Neuronal), isoform CRA_b
Gene Names:
CDH2 hCG_22518
Gene Names Orf:
hCG_22518
Gene Names Primary:
CDH2
Organism:
Homo sapiens (Human)

Structure

Length:
906
Sequence:
MCRIAGALRTLLPLLAALLQASVEASGEIALCKTGFPEDVYSAVLSKDVHEGQPLLNVKFSNCNGKRKVQYESSEPADFKVDEDGMVYAVRSFPLSSEHAKFLIYAQDKETQEKWQVAVKLSLKPTLTEESVKESAEVEEIVFPRQFSKHSGHLQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDREQIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGTVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRIVSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAIQTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLHAGTMLTTFTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPDPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLKIKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRMDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYGGGDD

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Cadherins are calcium-dependent cell adhesion proteins.
Gene Ontology Go:
apical plasma membrane
basolateral plasma membrane
fascia adherens
integral component of membrane
lamellipodium
plasma membrane raft
protein complex
synapse
calcium ion binding
blood vessel morphogenesis
brain morphogenesis
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell migration
cell-cell adhesion mediated by cadherin
cerebral cortex development
establishment of protein localization to plasma membrane
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
homeostasis of number of cells
homophilic cell adhesion via plasma membrane adhesion molecules
negative regulation of canonical Wnt signaling pathway
neuroepithelial cell differentiation
neuroligin clustering involved in postsynaptic membrane assembly
neuronal stem cell population maintenance
positive regulation of MAPK cascade
positive regulation of synaptic vesicle clustering
protein heterooligomerization
radial glial cell differentiation
regulation of axonogenesis
regulation of myelination
regulation of oligodendrocyte progenitor proliferation
regulation of postsynaptic density protein 95 clustering
regulation of Rho protein signal transduction
striated muscle cell differentiation
Gene Ontology Biological Process:
blood vessel morphogenesis
brain morphogenesis
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell-cell adhesion mediated by cadherin
cell migration
cerebral cortex development
establishment of protein localization to plasma membrane
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
homeostasis of number of cells
homophilic cell adhesion via plasma membrane adhesion molecules
negative regulation of canonical Wnt signaling pathway
neuroepithelial cell differentiation
neuroligin clustering involved in postsynaptic membrane assembly
neuronal stem cell population maintenance
positive regulation of MAPK cascade
positive regulation of synaptic vesicle clustering
protein heterooligomerization
radial glial cell differentiation
regulation of axonogenesis
regulation of myelination
regulation of oligodendrocyte progenitor proliferation
regulation of postsynaptic density protein 95 clustering
regulation of Rho protein signal transduction
striated muscle cell differentiation
Gene Ontology Molecular Function:
calcium ion binding
Gene Ontology Cellular Component:
apical plasma membrane
basolateral plasma membrane
fascia adherens
integral component of membrane
lamellipodium
plasma membrane raft
protein complex
synapse
Keywords:
Calcium
Cell adhesion
Cell membrane
Membrane
Repeat
Signal
Transmembrane
Transmembrane helix

Publication

PubMed ID:
11181995