Names & Taxonomy
- Uniprot ID:
- C9J381
- Entry Name:
- C9J381_HUMAN
- Status:
- unreviewed
- Protein Names:
- Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)
- Gene Names:
- IMPDH1
- Gene Names Primary:
- IMPDH1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 513
- Sequence:
- MADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKFEQGFITDPVVLSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDCDELVAIIARTDLKKNRDYPLASKDSQKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPIIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAMEKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLRSMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY
- Proteomes:
- UP000005640
Function
- Pathway:
- Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.
- Catalytic Activity:
- Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH.
- Active Site:
- ACT_SITE 330 330 Thioimidate intermediate.
- Gene Ontology Go:
- IMP dehydrogenase activity
metal ion binding
GMP biosynthetic process - Gene Ontology Biological Process:
- GMP biosynthetic process
- Gene Ontology Molecular Function:
- IMP dehydrogenase activity
metal ion binding - Keywords:
- Complete proteome
GMP biosynthesis
Metal-binding
NAD
Oxidoreductase
Potassium
Proteomics identification
Purine biosynthesis
Reference proteome