Names & Taxonomy

Uniprot ID:
B7Z3Z4
Entry Name:
B7Z3Z4_HUMAN
Status:
unreviewed
Protein Names:
Beta-site APP-cleaving enzyme 1, isoform CRA_f (cDNA FLJ54693, highly similar to Beta-secretase 1 (EC 3.4.23.46))
Gene Names:
BACE1 hCG_37942
Gene Names Orf:
hCG_37942
Gene Names Primary:
BACE1
Organism:
Homo sapiens (Human)

Structure

Length:
401
Sequence:
MVPFIYLQAHFTLCSGWSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK

Function

Gene Ontology Go:
integral component of membrane
aspartic-type endopeptidase activity
Gene Ontology Molecular Function:
aspartic-type endopeptidase activity
Gene Ontology Cellular Component:
integral component of membrane
Keywords:
Membrane
Transmembrane
Transmembrane helix

Publication

PubMed ID:
11181995