Names & Taxonomy

Uniprot ID:
B4DY26
Entry Name:
B4DY26_HUMAN
Status:
unreviewed
Protein Names:
Receptor protein serine/threonine kinase (EC 2.7.11.30)
Gene Names:
TGFBR1
Gene Names Primary:
TGFBR1
Organism:
Homo sapiens (Human)

Structure

Length:
434
Sequence:
MCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
Proteomes:
UP000005640

Function

Catalytic Activity:
ATP + = ADP + phosphate.
Gene Ontology Go:
cell
integral component of membrane
intracellular
membrane
ATP binding
receptor signaling protein activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta binding
transforming growth factor beta receptor activity, type I
activin receptor signaling pathway
cardiac epithelial to mesenchymal transition
endothelial cell activation
heart development
intracellular signal transduction
mesenchymal cell differentiation
positive regulation of endothelial cell proliferation
positive regulation of gene expression
positive regulation of transcription, DNA-templated
regulation of epithelial to mesenchymal transition
regulation of gene expression
transforming growth factor beta receptor signaling pathway
Gene Ontology Biological Process:
activin receptor signaling pathway
cardiac epithelial to mesenchymal transition
endothelial cell activation
heart development
intracellular signal transduction
mesenchymal cell differentiation
positive regulation of endothelial cell proliferation
positive regulation of gene expression
positive regulation of transcription, DNA-templated
regulation of epithelial to mesenchymal transition
regulation of gene expression
transforming growth factor beta receptor signaling pathway
Gene Ontology Molecular Function:
ATP binding
receptor signaling protein activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta binding
transforming growth factor beta receptor activity, type I
Gene Ontology Cellular Component:
cell
integral component of membrane
intracellular
membrane
Keywords:
ATP-binding
Complete proteome
Kinase
Membrane
Nucleotide-binding
Proteomics identification
Receptor
Reference proteome
Serine/threonine-protein kinase
Transferase
Transmembrane
Transmembrane helix

Publication

PubMed ID:
15164053 19369195