Names & Taxonomy
- Uniprot ID:
- B4DTU7
- Entry Name:
- B4DTU7_HUMAN
- Status:
- unreviewed
- Protein Names:
- 10-formyltetrahydrofolate dehydrogenase (EC 1.5.1.6)
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 923
- Sequence:
- MLRRGSQALRRFSTGRVYFKNKLKLALIGQSLFGQEVYSHLRKEGHRVVGVFTVPDKDGKADPLALAAEKDGTPVFKLPKWRVKGKTIKEVAEAYRSVGAELNVLPFCTQFIPMDIIDSPKHGSIIYHPSILPRHRGASAINWTLIMGDKKAGFSVFWADDGLDTGPILLQRSCDVEPNDTVDALYNRFLFPEGIKAMVEAVQLIADGKAPRIPQPEEGATYEGIQKKENAEISWDQSAEVLHNWIRGHDKVPGAWTEINGQMVTFYGSTLLNSSVPPGEPLEIKGAKKPGLVTKNGLVLFGNDGKALTVRNLQFEDGKMIPASQYFSTGETSVVELTAEEVKVAETIKVIWAGILSNVPIIEDSTDFFKSGAGSMDVARLVEEIRQKCGGLQLQNEDVYMATKFEGFIQKVVRKLRGEDQEVELVVDYISKEVNEIMVKMPYQCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVTLEY
Function
- Catalytic Activity:
- 10-formyltetrahydrofolate + NADP(+) + H(2)O = tetrahydrofolate + CO(2) + NADPH.
- Active Site:
- ACT_SITE 128 128 Proton donor.
- Gene Ontology Go:
- cytoplasm
formyltetrahydrofolate dehydrogenase activity
hydroxymethyl-, formyl- and related transferase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
10-formyltetrahydrofolate catabolic process
biosynthetic process
one-carbon metabolic process - Gene Ontology Biological Process:
- 10-formyltetrahydrofolate catabolic process
biosynthetic process
one-carbon metabolic process - Gene Ontology Molecular Function:
- formyltetrahydrofolate dehydrogenase activity
hydroxymethyl-, formyl- and related transferase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor - Gene Ontology Cellular Component:
- cytoplasm
- Keywords:
- NADP
One-carbon metabolism
Oxidoreductase