Names & Taxonomy
- Uniprot ID:
- B2R9M7
- Entry Name:
- B2R9M7_HUMAN
- Status:
- unreviewed
- Protein Names:
- Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon)
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 737
- Sequence:
- MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALPFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLMP
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Enzyme Regulation:
- ENZYME REGULATION: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
- Gene Ontology Go:
- cytoskeleton
nucleus
perinuclear region of cytoplasm
plasma membrane
ATP binding
calcium-independent protein kinase C activity
metal ion binding
cell adhesion
cell cycle
cell division
intracellular signal transduction - Gene Ontology Biological Process:
- cell adhesion
cell cycle
cell division
intracellular signal transduction - Gene Ontology Molecular Function:
- ATP binding
calcium-independent protein kinase C activity
metal ion binding - Gene Ontology Cellular Component:
- cytoskeleton
nucleus
perinuclear region of cytoplasm
plasma membrane - Keywords:
- ATP-binding
Cell adhesion
Cell cycle
Cell division
Cell membrane
Cytoplasm
Cytoskeleton
Kinase
Membrane
Metal-binding
Nucleotide-binding
Nucleus
Serine/threonine-protein kinase
Transferase
Zinc
Zinc-finger