Names & Taxonomy
- Uniprot ID:
- A0A024R452
- Entry Name:
- A0A024R452_HUMAN
- Status:
- unreviewed
- Protein Names:
- EPH receptor A4, isoform CRA_a
- Gene Names:
- EPHA4 hCG_1811889
- Gene Names Orf:
- hCG_1811889
- Gene Names Primary:
- EPHA4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 986
- Sequence:
- MAGIFYFALFSCLFGICDAVTGSRVYPANEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNTPIRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESDNDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALVSVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEKDVPKMYCGADGEWLVPIGNCLCNAGHEERSGECQACKIGYYKALSTDATCAKCPPHSYSVWEGATSCTCDRGFFRADNDAASMPCTRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDISYNVVCKKCGAGDPSKCRPCGSGVHYTPQQNGLKTTKVSITDLLAHTNYTFEIWAVNGVSKYNPNPDQSVSVTVTTNQAAPSSIALVQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYEKDQNERSYRIVRTAARNTDIKGLNPLTSYVFHVRARTAAGYGDFSEPLEVTTNTVPSRIIGDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEKHLNQGVRTYVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGTESSRPNTALLDPSSPEFSAVVSVGDWLQAIKMDRYKDNFTAAGYTTLEAVVHVNQEDLARIGITAITHQNKILSSVQAMRTQMQQMHGRMVPV
Function
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Active Site:
- ACT_SITE 746 746 Proton acceptor.
- Gene Ontology Go:
- axon terminus
axonal growth cone
cell surface
dendritic spine
early endosome membrane
endoplasmic reticulum
filopodium
Golgi apparatus
integral component of plasma membrane
mitochondrial outer membrane
neuromuscular junction
perikaryon
postsynaptic density
ATP binding
GPI-linked ephrin receptor activity
transmembrane-ephrin receptor activity
adult walking behavior
corticospinal tract morphogenesis
fasciculation of motor neuron axon
fasciculation of sensory neuron axon
glial cell migration
motor neuron axon guidance
negative regulation of axon regeneration
nephric duct morphogenesis
positive regulation of dendrite morphogenesis
positive regulation of JUN kinase activity
regulation of astrocyte differentiation
regulation of axonogenesis
regulation of dendritic spine morphogenesis
regulation of GTPase activity - Gene Ontology Biological Process:
- adult walking behavior
corticospinal tract morphogenesis
fasciculation of motor neuron axon
fasciculation of sensory neuron axon
glial cell migration
motor neuron axon guidance
negative regulation of axon regeneration
nephric duct morphogenesis
positive regulation of dendrite morphogenesis
positive regulation of JUN kinase activity
regulation of astrocyte differentiation
regulation of axonogenesis
regulation of dendritic spine morphogenesis
regulation of GTPase activity - Gene Ontology Molecular Function:
- ATP binding
GPI-linked ephrin receptor activity
transmembrane-ephrin receptor activity - Gene Ontology Cellular Component:
- axonal growth cone
axon terminus
cell surface
dendritic spine
early endosome membrane
endoplasmic reticulum
filopodium
Golgi apparatus
integral component of plasma membrane
mitochondrial outer membrane
neuromuscular junction
perikaryon
postsynaptic density - Keywords:
- ATP-binding
Kinase
Membrane
Nucleotide-binding
Receptor
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase
Publication
- PubMed ID:
- 11181995