Names & Taxonomy
- Uniprot ID:
- A8K4G2
- Entry Name:
- A8K4G2_HUMAN
- Status:
- unreviewed
- Protein Names:
- Tyrosine-protein kinase (EC 2.7.10.2)
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 635
- Sequence:
- MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLINLCWTYDVENRPGFAAVELRLRNYYYDVAN
Function
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Active Site:
- ACT_SITE 494 494 Proton acceptor.
- Gene Ontology Go:
- cytoplasm
ATP binding
non-membrane spanning protein tyrosine kinase activity
intracellular signal transduction - Gene Ontology Biological Process:
- intracellular signal transduction
- Gene Ontology Molecular Function:
- ATP binding
non-membrane spanning protein tyrosine kinase activity - Gene Ontology Cellular Component:
- cytoplasm
- Keywords:
- ATP-binding
Kinase
Nucleotide-binding
Transferase
Tyrosine-protein kinase