Names & Taxonomy

Uniprot ID:
A0A024R3E8
Entry Name:
A0A024R3E8_HUMAN
Status:
unreviewed
Protein Names:
Beta-site APP-cleaving enzyme 1, isoform CRA_c
Gene Names:
BACE1 hCG_37942
Gene Names Orf:
hCG_37942
Gene Names Primary:
BACE1
Organism:
Homo sapiens (Human)

Structure

Length:
476
Sequence:
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK

Function

Gene Ontology Go:
integral component of membrane
aspartic-type endopeptidase activity
Gene Ontology Molecular Function:
aspartic-type endopeptidase activity
Gene Ontology Cellular Component:
integral component of membrane
Keywords:
Aspartyl protease
Hydrolase
Membrane
Protease
Signal
Transmembrane
Transmembrane helix

Publication

PubMed ID:
11181995