Names & Taxonomy
- Uniprot ID:
- X5DNK3
- Entry Name:
- X5DNK3_HUMAN
- Status:
- unreviewed
- Protein Names:
- Receptor protein-tyrosine kinase (EC 2.7.10.1) (Fragment)
- Gene Names:
- ERBB2
- Gene Names Primary:
- ERBB2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1255
- Sequence:
- MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
Function
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Gene Ontology Go:
- apical plasma membrane
cytoplasm
cytoplasmic vesicle
integral component of membrane
myelin sheath
nucleus
plasma membrane
ATP binding
receptor signaling protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
heart development
motor neuron axon guidance
myelination
negative regulation of immature T cell proliferation in thymus
neuromuscular junction development
oligodendrocyte differentiation
peripheral nervous system development
positive regulation of GTPase activity
positive regulation of protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway - Gene Ontology Biological Process:
- heart development
motor neuron axon guidance
myelination
negative regulation of immature T cell proliferation in thymus
neuromuscular junction development
oligodendrocyte differentiation
peripheral nervous system development
positive regulation of GTPase activity
positive regulation of protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway - Gene Ontology Molecular Function:
- ATP binding
receptor signaling protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity - Gene Ontology Cellular Component:
- apical plasma membrane
cytoplasm
cytoplasmic vesicle
integral component of membrane
myelin sheath
nucleus
plasma membrane - Keywords:
- ATP-binding
Kinase
Membrane
Nucleotide-binding
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase
Publication
- PubMed ID:
- 24722188