Names & Taxonomy

Uniprot ID:
Q9Y6R1
Entry Name:
S4A4_HUMAN
Status:
reviewed
Protein Names:
Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1)
Gene Names:
SLC4A4 NBC NBC1 NBCE1
Gene Names Primary:
SLC4A4
Organism:
Homo sapiens (Human)

Structure

Length:
1079
Sequence:
MEDEAVLDRGASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRRHKRKTGHKEKKEKERISENYSDKSDIENADESSSSILKPLISPAAERIRFILGEEDDSPAPPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCMEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKKSNLRSLADIGKTVSSASRMFTNPDNGSPAMTHRNLTSSSLNDISDKPEKDQLKNKFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGGGGHGDCEELQRTGRFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEFRLWIGLWSAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSNFKVGYNTLFSCTCVPPDPANISISNDTTLAPEYLPTMSSTDMYHNTTFDWAFLSKKECSKYGGNLVGNNCNFVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFAIILSILIFCVIDALVGVDTPKLIVPSEFKPTSPNRGWFVPPFGENPWWVCLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWILKSTVAAIIFPVMILALVAVRKGMDYLFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKGSLDSDNDDSDCPYSEKVPSIKIPMDIMEQQPFLSDSKPSDRERSPTFLERHTSC
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Basolateral cell membrane

Function

Function:
Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.
Enzyme Regulation:
ENZYME REGULATION: Inhibited by stilbene derivatives and regulated by cyclic AMP.
Cross Reference Drug Bank:
DB01390
Gene Ontology Go:
basolateral plasma membrane
extracellular exosome
integral component of plasma membrane
plasma membrane
inorganic anion exchanger activity
sodium:bicarbonate symporter activity
bicarbonate transport
ion transport
sodium ion transmembrane transport
sodium ion transport
transmembrane transport
transport
Gene Ontology Biological Process:
bicarbonate transport
ion transport
sodium ion transmembrane transport
sodium ion transport
transmembrane transport
transport
Gene Ontology Molecular Function:
inorganic anion exchanger activity
sodium:bicarbonate symporter activity
Gene Ontology Cellular Component:
basolateral plasma membrane
extracellular exosome
integral component of plasma membrane
plasma membrane
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Reference proteome
Retinitis pigmentosa
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport
Interacts With:
P48283

Publication

PubMed ID:
9235899 9651366 10069984 12907161 15815621 15489334 11744745 11743927 12411514 12604466 14559244 12534288 14567693 12730338 15329059 15273250 15218065 15563508 15817634 16769890 24275569 25568315 10545938 15471865 15713912 15930088 16636648 17661077