Names & Taxonomy
- Uniprot ID:
- Q9Y6R1
- Entry Name:
- S4A4_HUMAN
- Status:
- reviewed
- Protein Names:
- Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1)
- Gene Names:
- SLC4A4 NBC NBC1 NBCE1
- Gene Names Primary:
- SLC4A4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1079
- Sequence:
- MEDEAVLDRGASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRRHKRKTGHKEKKEKERISENYSDKSDIENADESSSSILKPLISPAAERIRFILGEEDDSPAPPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCMEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKKSNLRSLADIGKTVSSASRMFTNPDNGSPAMTHRNLTSSSLNDISDKPEKDQLKNKFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGGGGHGDCEELQRTGRFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEFRLWIGLWSAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSNFKVGYNTLFSCTCVPPDPANISISNDTTLAPEYLPTMSSTDMYHNTTFDWAFLSKKECSKYGGNLVGNNCNFVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFAIILSILIFCVIDALVGVDTPKLIVPSEFKPTSPNRGWFVPPFGENPWWVCLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWILKSTVAAIIFPVMILALVAVRKGMDYLFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKGSLDSDNDDSDCPYSEKVPSIKIPMDIMEQQPFLSDSKPSDRERSPTFLERHTSC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Basolateral cell membrane
Function
- Function:
- Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by stilbene derivatives and regulated by cyclic AMP.
- Cross Reference Drug Bank:
- DB01390
- Gene Ontology Go:
- basolateral plasma membrane
extracellular exosome
integral component of plasma membrane
plasma membrane
inorganic anion exchanger activity
sodium:bicarbonate symporter activity
bicarbonate transport
ion transport
sodium ion transmembrane transport
sodium ion transport
transmembrane transport
transport - Gene Ontology Biological Process:
- bicarbonate transport
ion transport
sodium ion transmembrane transport
sodium ion transport
transmembrane transport
transport - Gene Ontology Molecular Function:
- inorganic anion exchanger activity
sodium:bicarbonate symporter activity - Gene Ontology Cellular Component:
- basolateral plasma membrane
extracellular exosome
integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Reference proteome
Retinitis pigmentosa
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport - Interacts With:
- P48283