Names & Taxonomy
- Uniprot ID:
- Q9Y6F1
- Entry Name:
- PARP3_HUMAN
- Status:
- reviewed
- Protein Names:
- Poly [ADP-ribose] polymerase 3 (PARP-3) (hPARP-3) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 3) (ARTD3) (IRT1) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly[ADP-ribose] synthase 3) (pADPRT-3)
- Gene Names:
- PARP3 ADPRT3 ADPRTL3
- Gene Names Primary:
- PARP3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 533
- Sequence:
- MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGTQVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNHWGRVGEVGQSKINHFTRLEDAKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Core component of the centrosome. Preferentially localized to the daughter centriole throughout the cell cycle. According to PubMed:16924674, it is almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected.
Function
- Function:
- Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
- Catalytic Activity:
- NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
- Cross Reference Drug Bank:
- DB09074
- Gene Ontology Go:
- centriole
cytoplasm
nucleus
site of double-strand break
catalytic activity
DNA ligase (ATP) activity
NAD+ ADP-ribosyltransferase activity
DNA ligation involved in DNA repair
DNA repair
double-strand break repair
lagging strand elongation
positive regulation of DNA ligation
protein ADP-ribosylation
protein localization to site of double-strand break
regulation of mitotic spindle organization
telomere maintenance - Gene Ontology Biological Process:
- DNA ligation involved in DNA repair
DNA repair
double-strand break repair
lagging strand elongation
positive regulation of DNA ligation
protein ADP-ribosylation
protein localization to site of double-strand break
regulation of mitotic spindle organization
telomere maintenance - Gene Ontology Molecular Function:
- catalytic activity
DNA ligase (ATP) activity
NAD+ ADP-ribosyltransferase activity - Gene Ontology Cellular Component:
- centriole
cytoplasm
nucleus
site of double-strand break - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Cytoskeleton
Glycosyltransferase
NAD
Nucleus
Polymorphism
Reference proteome
Transferase