Names & Taxonomy

Uniprot ID:
Q9Y6F1
Entry Name:
PARP3_HUMAN
Status:
reviewed
Protein Names:
Poly [ADP-ribose] polymerase 3 (PARP-3) (hPARP-3) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 3) (ARTD3) (IRT1) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly[ADP-ribose] synthase 3) (pADPRT-3)
Gene Names:
PARP3 ADPRT3 ADPRTL3
Gene Names Primary:
PARP3
Organism:
Homo sapiens (Human)

Structure

Length:
533
Sequence:
MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGTQVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNHWGRVGEVGQSKINHFTRLEDAKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Core component of the centrosome. Preferentially localized to the daughter centriole throughout the cell cycle. According to PubMed:16924674, it is almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected.

Function

Function:
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
Catalytic Activity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
Cross Reference Drug Bank:
DB09074
Gene Ontology Go:
centriole
cytoplasm
nucleus
site of double-strand break
catalytic activity
DNA ligase (ATP) activity
NAD+ ADP-ribosyltransferase activity
DNA ligation involved in DNA repair
DNA repair
double-strand break repair
lagging strand elongation
positive regulation of DNA ligation
protein ADP-ribosylation
protein localization to site of double-strand break
regulation of mitotic spindle organization
telomere maintenance
Gene Ontology Biological Process:
DNA ligation involved in DNA repair
DNA repair
double-strand break repair
lagging strand elongation
positive regulation of DNA ligation
protein ADP-ribosylation
protein localization to site of double-strand break
regulation of mitotic spindle organization
telomere maintenance
Gene Ontology Molecular Function:
catalytic activity
DNA ligase (ATP) activity
NAD+ ADP-ribosyltransferase activity
Gene Ontology Cellular Component:
centriole
cytoplasm
nucleus
site of double-strand break
Keywords:
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Cytoskeleton
Glycosyltransferase
NAD
Nucleus
Polymorphism
Reference proteome
Transferase

Publication

PubMed ID:
10329013 12640039 16641997 15489334 17974005 16924674 20106667