Names & Taxonomy
- Uniprot ID:
- Q9Y663
- Entry Name:
- HS3SA_HUMAN
- Status:
- reviewed
- Protein Names:
- Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 (EC 2.8.2.30) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1) (3-OST-3A) (Heparan sulfate 3-O-sulfotransferase 3A1) (h3-OST-3A)
- Gene Names:
- HS3ST3A1 3OST3A1 HS3ST3A UNQ2551/PRO6180
- Gene Names Orf:
- UNQ2551/PRO6180
- Gene Names Primary:
- HS3ST3A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 406
- Sequence:
- MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCQTLSGPVVGLSGGGEEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPPAPRDDGEEAAWEEESPGLSGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRAVGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIVVVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLRHFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSRPHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWDG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Golgi apparatus membrane
Function
- Function:
- Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.
- Catalytic Activity:
- 3'-phosphoadenylyl sulfate + -glucosamine = adenosine 3',5'-bisphosphate + -glucosamine 3-sulfate.
- Gene Ontology Go:
- Golgi membrane
integral component of membrane
-glucosamine 3-sulfotransferase 3 activity
sulfotransferase activity
carbohydrate metabolic process
glycosaminoglycan biosynthetic process
glycosaminoglycan metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- carbohydrate metabolic process
glycosaminoglycan biosynthetic process
glycosaminoglycan metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- -glucosamine 3-sulfotransferase 3 activity
sulfotransferase activity - Gene Ontology Cellular Component:
- Golgi membrane
integral component of membrane - Keywords:
- 3D-structure
Complete proteome
Disulfide bond
Glycoprotein
Golgi apparatus
Membrane
Reference proteome
Signal-anchor
Transferase
Transmembrane
Transmembrane helix