Names & Taxonomy
- Uniprot ID:
- Q9Y5Y6
- Entry Name:
- ST14_HUMAN
- Status:
- reviewed
- Protein Names:
- Suppressor of tumorigenicity 14 protein (EC 3.4.21.109) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease 14) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein)
- Gene Names:
- ST14 PRSS14 SNC19 TADG15
- Gene Names Primary:
- ST14
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 855
- Sequence:
- MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKHGPGRWVVLAAVLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKVKDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFSIPQHLVEEAERVMAEERVVMLPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPSYNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIKENTGV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing.
- Catalytic Activity:
- Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position.
- Active Site:
- ACT_SITE 656 656 Charge relay system.; ACT_SITE 711 711 Charge relay system.; ACT_SITE 805 805 Charge relay system.
- Cross Reference Drug Bank:
- DB00013
- Gene Ontology Go:
- basolateral plasma membrane
extracellular exosome
extracellular space
extrinsic component of plasma membrane
integral component of plasma membrane
plasma membrane
serine-type endopeptidase activity
serine-type peptidase activity
epithelial cell morphogenesis involved in placental branching
keratinocyte differentiation
neural tube closure
proteolysis - Gene Ontology Biological Process:
- epithelial cell morphogenesis involved in placental branching
keratinocyte differentiation
neural tube closure
proteolysis - Gene Ontology Molecular Function:
- serine-type endopeptidase activity
serine-type peptidase activity - Gene Ontology Cellular Component:
- basolateral plasma membrane
extracellular exosome
extracellular space
extrinsic component of plasma membrane
integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Hydrolase
Hypotrichosis
Ichthyosis
Membrane
Polymorphism
Protease
Reference proteome
Repeat
Serine protease
Signal-anchor
Transmembrane
Transmembrane helix