Names & Taxonomy

Uniprot ID:
Q9Y4D2
Entry Name:
DGLA_HUMAN
Status:
reviewed
Protein Names:
Sn1-specific diacylglycerol lipase alpha (DGL-alpha) (EC 3.1.1.-) (Neural stem cell-derived dendrite regulator)
Gene Names:
DAGLA C11orf11 KIAA0659 NSDDR
Gene Names Primary:
DAGLA
Organism:
Homo sapiens (Human)

Structure

Length:
1042
Sequence:
MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGRGYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLTQYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQRNLRTYNLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGLVLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSQEMLRYKEVCYYMLFALAAYGWPMYLMRKPACGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLDENMTAVDIVYTSCHDAVYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVEGHHGTWLGHKGMVLSAEYIKKKLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAILSFLLRPQYPTLKCFAYSPPGGLLSEDAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQLLDVLQRSTKPKWRIIVGATKCIPKSELPEEVEVTTLASTRLWTHPSDLTIALSASTPLYPPGRIIHVVHNHPAEQCCCCEQEEPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGLNKVLENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPMPTGLALELPTADHRNSSVRSKSQSEMSLEGFSEGRLLSPVVAAAARQDPVELLLLSTQERLAAELQARRAPLATMESLSDTESLYSFDSRRSSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRTELLAADSLSKHSQDTQPLEAALGSGGVTPERPPSAAANDEEEEVGGGGGGPASRGELALHNGRLGDSPSPQVLEFAEFIDSLFNLDSKSSSFQDLYCMVVPESPTSDYAEGPKSPSQQEILLRAQFEPNLVPKPPRLFAGSADPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLAADKIRTSTPTGHGASPAKQDELVISAR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.
Cofactor:
COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=154.7 uM for diacylglycerol
Enzyme Regulation:
ENZYME REGULATION: Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by RHC80267, a drug that blocks 2-AG formation.
Active Site:
ACT_SITE 472 472 Charge relay system.
Gene Ontology Go:
integral component of membrane
plasma membrane
varicosity
hydrolase activity
metal ion binding
arachidonic acid metabolic process
blood coagulation
diacylglycerol catabolic process
endocannabinoid signaling pathway
neuroblast proliferation
neurotransmitter biosynthetic process
platelet activation
Gene Ontology Biological Process:
arachidonic acid metabolic process
blood coagulation
diacylglycerol catabolic process
endocannabinoid signaling pathway
neuroblast proliferation
neurotransmitter biosynthetic process
platelet activation
Gene Ontology Molecular Function:
hydrolase activity
metal ion binding
Gene Ontology Cellular Component:
integral component of membrane
plasma membrane
varicosity
Keywords:
Calcium
Cell membrane
Complete proteome
Glycoprotein
Hydrolase
Lipid degradation
Lipid metabolism
Membrane
Metal-binding
Neurodegeneration
Phosphoprotein
Polymorphism
Reference proteome
Spinocerebellar ataxia
Transmembrane
Transmembrane helix

Publication

PubMed ID:
9734811 12168954 15489334 14610053 16051747 18801880