Names & Taxonomy
- Uniprot ID:
- Q9Y345
- Entry Name:
- SC6A5_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5)
- Gene Names:
- SLC6A5 GLYT2 NET1
- Gene Names Primary:
- SLC6A5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 797
- Sequence:
- MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQTFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQGAQASPPPGSSGPGNALHCKIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTSSLGLKLPVKDLELGTQC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses.
- Cross Reference Drug Bank:
- DB00145
- Gene Ontology Go:
- integral component of membrane
integral component of plasma membrane
plasma membrane
glycine:sodium symporter activity
metal ion binding
neurotransmitter:sodium symporter activity
glycine import
synaptic transmission
synaptic transmission, glycinergic
transmembrane transport
transport - Gene Ontology Biological Process:
- glycine import
synaptic transmission
synaptic transmission, glycinergic
transmembrane transport
transport - Gene Ontology Molecular Function:
- glycine:sodium symporter activity
metal ion binding
neurotransmitter:sodium symporter activity - Gene Ontology Cellular Component:
- integral component of membrane
integral component of plasma membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Membrane
Metal-binding
Neurotransmitter transport
Phosphoprotein
Polymorphism
Reference proteome
Sodium
Symport
Transmembrane
Transmembrane helix
Transport