Names & Taxonomy

Uniprot ID:
Q9Y345
Entry Name:
SC6A5_HUMAN
Status:
reviewed
Protein Names:
Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5)
Gene Names:
SLC6A5 GLYT2 NET1
Gene Names Primary:
SLC6A5
Organism:
Homo sapiens (Human)

Structure

Length:
797
Sequence:
MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQTFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQGAQASPPPGSSGPGNALHCKIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTSSLGLKLPVKDLELGTQC
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses.
Cross Reference Drug Bank:
DB00145
Gene Ontology Go:
integral component of membrane
integral component of plasma membrane
plasma membrane
glycine:sodium symporter activity
metal ion binding
neurotransmitter:sodium symporter activity
glycine import
synaptic transmission
synaptic transmission, glycinergic
transmembrane transport
transport
Gene Ontology Biological Process:
glycine import
synaptic transmission
synaptic transmission, glycinergic
transmembrane transport
transport
Gene Ontology Molecular Function:
glycine:sodium symporter activity
metal ion binding
neurotransmitter:sodium symporter activity
Gene Ontology Cellular Component:
integral component of membrane
integral component of plasma membrane
plasma membrane
Keywords:
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Membrane
Metal-binding
Neurotransmitter transport
Phosphoprotein
Polymorphism
Reference proteome
Sodium
Symport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
9845349 10381548 10606742 16554811 15489334 16751771 16959974