Names & Taxonomy
- Uniprot ID:
- Q9Y2Z4
- Entry Name:
- SYYM_HUMAN
- Status:
- reviewed
- Protein Names:
- Tyrosine--tRNA ligase, mitochondrial (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS)
- Gene Names:
- YARS2 CGI-04
- Gene Names Orf:
- CGI-04
- Gene Names Primary:
- YARS2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 477
- Sequence:
- MAAPILRSFSWGRWSGTLNLSVLLPLGLRKAHSGAQGLLAAQKARGLFKDFFPETGTKIELPELFDRGTASFPQTIYCGFDPTADSLHVGHLLALLGLFHLQRAGHNVIALVGGATARLGDPSGRTKEREALETERVRANARALRLGLEALAANHQQLFTDGRSWGSFTVLDNSAWYQKQHLVDFLAAVGGHFRMGTLLSRQSVQLRLKSPEGMSLAEFFYQVLQAYDFYYLFQRYGCRVQLGGSDQLGNIMSGYEFINKLTGEDVFGITVPLITSTTGAKLGKSAGNAVWLNRDKTSPFELYQFFVRQPDDSVERYLKLFTFLPLPEIDHIMQLHVKEPERRGPQKRLAAEVTKLVHGREGLDSAKRCTQALYHSSIDALEVMSDQELKELFKEAPFSEFFLDPGTSVLDTCRKANAIPDGPRGYRMITEGGVSINHQQVTNPESVLIVGQHILKNGLSLLKIGKRNFYIIKWLQL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix
Function
- Function:
- Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
- Catalytic Activity:
- ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).
- Cross Reference Drug Bank:
- DB00135
- Gene Ontology Go:
- cytosol
mitochondrial matrix
mitochondrion
ATP binding
poly(A) RNA binding
protein homodimerization activity
tRNA binding
tyrosine binding
tyrosine-tRNA ligase activity
gene expression
mitochondrial tyrosyl-tRNA aminoacylation
translation
tRNA aminoacylation
tRNA aminoacylation for protein translation - Gene Ontology Biological Process:
- gene expression
mitochondrial tyrosyl-tRNA aminoacylation
translation
tRNA aminoacylation
tRNA aminoacylation for protein translation - Gene Ontology Molecular Function:
- ATP binding
poly(A) RNA binding
protein homodimerization activity
tRNA binding
tyrosine binding
tyrosine-tRNA ligase activity - Gene Ontology Cellular Component:
- cytosol
mitochondrial matrix
mitochondrion - Keywords:
- 3D-structure
ATP-binding
Acetylation
Aminoacyl-tRNA synthetase
Complete proteome
Disease mutation
Ligase
Mitochondrion
Nucleotide-binding
Polymorphism
Protein biosynthesis
Reference proteome
Transit peptide - Interacts With:
- Q8IZU0