Names & Taxonomy

Uniprot ID:
Q9Y2Z4
Entry Name:
SYYM_HUMAN
Status:
reviewed
Protein Names:
Tyrosine--tRNA ligase, mitochondrial (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS)
Gene Names:
YARS2 CGI-04
Gene Names Orf:
CGI-04
Gene Names Primary:
YARS2
Organism:
Homo sapiens (Human)

Structure

Length:
477
Sequence:
MAAPILRSFSWGRWSGTLNLSVLLPLGLRKAHSGAQGLLAAQKARGLFKDFFPETGTKIELPELFDRGTASFPQTIYCGFDPTADSLHVGHLLALLGLFHLQRAGHNVIALVGGATARLGDPSGRTKEREALETERVRANARALRLGLEALAANHQQLFTDGRSWGSFTVLDNSAWYQKQHLVDFLAAVGGHFRMGTLLSRQSVQLRLKSPEGMSLAEFFYQVLQAYDFYYLFQRYGCRVQLGGSDQLGNIMSGYEFINKLTGEDVFGITVPLITSTTGAKLGKSAGNAVWLNRDKTSPFELYQFFVRQPDDSVERYLKLFTFLPLPEIDHIMQLHVKEPERRGPQKRLAAEVTKLVHGREGLDSAKRCTQALYHSSIDALEVMSDQELKELFKEAPFSEFFLDPGTSVLDTCRKANAIPDGPRGYRMITEGGVSINHQQVTNPESVLIVGQHILKNGLSLLKIGKRNFYIIKWLQL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion matrix

Function

Function:
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Catalytic Activity:
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).
Cross Reference Drug Bank:
DB00135
Gene Ontology Go:
cytosol
mitochondrial matrix
mitochondrion
ATP binding
poly(A) RNA binding
protein homodimerization activity
tRNA binding
tyrosine binding
tyrosine-tRNA ligase activity
gene expression
mitochondrial tyrosyl-tRNA aminoacylation
translation
tRNA aminoacylation
tRNA aminoacylation for protein translation
Gene Ontology Biological Process:
gene expression
mitochondrial tyrosyl-tRNA aminoacylation
translation
tRNA aminoacylation
tRNA aminoacylation for protein translation
Gene Ontology Molecular Function:
ATP binding
poly(A) RNA binding
protein homodimerization activity
tRNA binding
tyrosine binding
tyrosine-tRNA ligase activity
Gene Ontology Cellular Component:
cytosol
mitochondrial matrix
mitochondrion
Keywords:
3D-structure
ATP-binding
Acetylation
Aminoacyl-tRNA synthetase
Complete proteome
Disease mutation
Ligase
Mitochondrion
Nucleotide-binding
Polymorphism
Protein biosynthesis
Reference proteome
Transit peptide
Interacts With:
Q8IZU0

Publication

PubMed ID:
10810093 14702039 16541075 15489334 15779907 19608861 21269460 25944712 20598274 22504945