Names & Taxonomy
- Uniprot ID:
- Q9Y2G3
- Entry Name:
- AT11B_HUMAN
- Status:
- reviewed
- Protein Names:
- Probable phospholipid-transporting ATPase IF (EC 3.6.3.1) (ATPase IR) (ATPase class VI type 11B) (P4-ATPase flippase complex alpha subunit ATP11B)
- Gene Names:
- ATP11B ATPIF ATPIR KIAA0956
- Gene Names Primary:
- ATP11B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1177
- Sequence:
- MWRWIRQQLGFDPPHQSDTRTIYVANRFPQNGLYTPQKFIDNRIISSKYTVWNFVPKNLFEQFRRVANFYFLIIFLVQLMIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHNSDNEVNGAPVYVVRSGGLVKTRSKNIRVGDIVRIAKDEIFPADLVLLSSDRLDGSCHVTTASLDGETNLKTHVAVPETALLQTVANLDTLVAVIECQQPEADLYRFMGRMIITQQMEEIVRPLGPESLLLRGARLKNTKEIFGVAVYTGMETKMALNYKSKSQKRSAVEKSMNTFLIIYLVILISEAVISTILKYTWQAEEKWDEPWYNQKTEHQRNSSKILRFISDFLAFLVLYNFIIPISLYVTVEMQKFLGSFFIGWDLDLYHEESDQKAQVNTSDLNEELGQVEYVFTDKTGTLTENEMQFRECSINGMKYQEINGRLVPEGPTPDSSEGNLSYLSSLSHLNNLSHLTTSSSFRTSPENETELIKEHDLFFKAVSLCHTVQISNVQTDCTGDGPWQSNLAPSQLEYYASSPDEKALVEAAARIGIVFIGNSEETMEVKTLGKLERYKLLHILEFDSDRRRMSVIVQAPSGEKLLFAKGAESSILPKCIGGEIEKTRIHVDEFALKGLRTLCIAYRKFTSKEYEEIDKRIFEARTALQQREEKLAAVFQFIEKDLILLGATAVEDRLQDKVRETIEALRMAGIKVWVLTGDKHETAVSVSLSCGHFHRTMNILELINQKSDSECAEQLRQLARRITEDHVIQHGLVVDGTSLSLALREHEKLFMEVCRNCSAVLCCRMAPLQKAKVIRLIKISPEKPITLAVGDGANDVSMIQEAHVGIGIMGKEGRQAARNSDYAIARFKFLSKLLFVHGHFYYIRIATLVQYFFYKNVCFITPQFLYQFYCLFSQQTLYDSVYLTLYNICFTSLPILIYSLLEQHVDPHVLQNKPTLYRDISKNRLLSIKTFLYWTILGFSHAFIFFFGSYLLIGKDTSLLGNGQMFGNWTFGTLVFTVMVITVTVKMALETHFWTWINHLVTWGSIIFYFVFSLFYGGILWPFLGSQNMYFVFIQLLSSGSAWFAIILMVVTCLFLDIIKKVFDRHLHPTSTEKAQLTETNAGIKCLDSMCCFPEGEAACASVGRMLERVIGRCSPTHISRSWSASDPFYTNDRSILTLSTMDSSTC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Recycling endosome membrane
Function
- Function:
- Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). Involved in regulation of sensitivity to cisplatin; may contribute to secretory vesicle transport of cisplatin from Golgi to plasma membrane.
- Catalytic Activity:
- ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).
- Active Site:
- ACT_SITE 407 407 4-aspartylphosphate intermediate.
- Gene Ontology Go:
- early endosome
endoplasmic reticulum
Golgi apparatus
integral component of membrane
membrane
nuclear inner membrane
plasma membrane
recycling endosome
recycling endosome membrane
ATP binding
ion transmembrane transporter activity
magnesium ion binding
phospholipid-translocating ATPase activity
aminophospholipid transport
ion transmembrane transport
ion transport
phospholipid translocation
transmembrane transport - Gene Ontology Biological Process:
- aminophospholipid transport
ion transmembrane transport
ion transport
phospholipid translocation
transmembrane transport - Gene Ontology Molecular Function:
- ATP binding
ion transmembrane transporter activity
magnesium ion binding
phospholipid-translocating ATPase activity - Gene Ontology Cellular Component:
- early endosome
endoplasmic reticulum
Golgi apparatus
integral component of membrane
membrane
nuclear inner membrane
plasma membrane
recycling endosome
recycling endosome membrane - Keywords:
- ATP-binding
Complete proteome
Endoplasmic reticulum
Endosome
Golgi apparatus
Hydrolase
Lipid transport
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix
Transport