Names & Taxonomy
- Uniprot ID:
- Q9Y2D0
- Entry Name:
- CAH5B_HUMAN
- Status:
- reviewed
- Protein Names:
- Carbonic anhydrase 5B, mitochondrial (EC 4.2.1.1) (Carbonate dehydratase VB) (Carbonic anhydrase VB) (CA-VB)
- Gene Names:
- CA5B
- Gene Names Primary:
- CA5B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 317
- Sequence:
- MVVMNSLRVILQASPGKLLWRKFQIPRFMPARPCSLYTCTYKTRNRALHPLWESVDLVPGGDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDSTDKSVIKGGPLEHNYRLKQFHFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDYVLNVQAKPKPATSQATP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion.
Function
- Function:
- Reversible hydration of carbon dioxide.
- Catalytic Activity:
- H(2)CO(3) = CO(2) + H(2)O.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet (phosphonoformate trisodium salt).
- Cross Reference Drug Bank:
- DB00909
- Gene Ontology Go:
- mitochondrial matrix
mitochondrion
carbonate dehydratase activity
zinc ion binding
bicarbonate transport
one-carbon metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- bicarbonate transport
one-carbon metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- carbonate dehydratase activity
zinc ion binding - Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrion - Keywords:
- Complete proteome
Lyase
Metal-binding
Mitochondrion
Reference proteome
Transit peptide
Zinc