Names & Taxonomy
- Uniprot ID:
- Q9Y219
- Entry Name:
- JAG2_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein jagged-2 (Jagged2) (hJ2)
- Gene Names:
- JAG2
- Gene Names Primary:
- JAG2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1238
- Sequence:
- MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSSTGLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRNPIERPGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHKFTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
calcium ion binding
growth factor activity
Notch binding
auditory receptor cell fate commitment
cell cycle
cell differentiation
epithelial cell apoptotic process involved in palatal shelf morphogenesis
gamma-delta T cell differentiation
in utero embryonic development
morphogenesis of embryonic epithelium
Notch receptor processing
Notch signaling pathway
odontogenesis of dentin-containing tooth
positive regulation of Notch signaling pathway
regulation of cell adhesion
regulation of cell migration
regulation of cell proliferation
respiratory system process
skeletal system development
spermatogenesis
T cell differentiation
thymic T cell selection - Gene Ontology Biological Process:
- auditory receptor cell fate commitment
cell cycle
cell differentiation
epithelial cell apoptotic process involved in palatal shelf morphogenesis
gamma-delta T cell differentiation
in utero embryonic development
morphogenesis of embryonic epithelium
Notch receptor processing
Notch signaling pathway
odontogenesis of dentin-containing tooth
positive regulation of Notch signaling pathway
regulation of cell adhesion
regulation of cell migration
regulation of cell proliferation
respiratory system process
skeletal system development
spermatogenesis
T cell differentiation
thymic T cell selection - Gene Ontology Molecular Function:
- calcium ion binding
growth factor activity
Notch binding - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Calcium
Complete proteome
Developmental protein
Disulfide bond
EGF-like domain
Glycoprotein
Membrane
Notch signaling pathway
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- Q5VTD9