Names & Taxonomy

Uniprot ID:
Q9Y219
Entry Name:
JAG2_HUMAN
Status:
reviewed
Protein Names:
Protein jagged-2 (Jagged2) (hJ2)
Gene Names:
JAG2
Gene Names Primary:
JAG2
Organism:
Homo sapiens (Human)

Structure

Length:
1238
Sequence:
MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSSTGLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRNPIERPGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHKFTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Function

Function:
Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).
Gene Ontology Go:
integral component of plasma membrane
plasma membrane
calcium ion binding
growth factor activity
Notch binding
auditory receptor cell fate commitment
cell cycle
cell differentiation
epithelial cell apoptotic process involved in palatal shelf morphogenesis
gamma-delta T cell differentiation
in utero embryonic development
morphogenesis of embryonic epithelium
Notch receptor processing
Notch signaling pathway
odontogenesis of dentin-containing tooth
positive regulation of Notch signaling pathway
regulation of cell adhesion
regulation of cell migration
regulation of cell proliferation
respiratory system process
skeletal system development
spermatogenesis
T cell differentiation
thymic T cell selection
Gene Ontology Biological Process:
auditory receptor cell fate commitment
cell cycle
cell differentiation
epithelial cell apoptotic process involved in palatal shelf morphogenesis
gamma-delta T cell differentiation
in utero embryonic development
morphogenesis of embryonic epithelium
Notch receptor processing
Notch signaling pathway
odontogenesis of dentin-containing tooth
positive regulation of Notch signaling pathway
regulation of cell adhesion
regulation of cell migration
regulation of cell proliferation
respiratory system process
skeletal system development
spermatogenesis
T cell differentiation
thymic T cell selection
Gene Ontology Molecular Function:
calcium ion binding
growth factor activity
Notch binding
Gene Ontology Cellular Component:
integral component of plasma membrane
plasma membrane
Keywords:
Alternative splicing
Calcium
Complete proteome
Developmental protein
Disulfide bond
EGF-like domain
Glycoprotein
Membrane
Notch signaling pathway
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Interacts With:
Q5VTD9

Publication

PubMed ID:
9315665 10079256 10662552 9486542