Names & Taxonomy
- Uniprot ID:
- Q9Y210
- Entry Name:
- TRPC6_HUMAN
- Status:
- reviewed
- Protein Names:
- Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6)
- Gene Names:
- TRPC6 TRP6
- Gene Names Primary:
- TRPC6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 931
- Sequence:
- MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGSDNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRELGEKLSMEPNQEETNR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
- Gene Ontology Go:
- cytoplasm
cytosol
integral component of plasma membrane
membrane
plasma membrane
slit diaphragm
inositol 1,4,5 trisphosphate binding
store-operated calcium channel activity
aging
axon guidance
blood coagulation
calcium ion transmembrane transport
cation transport
cellular response to hydrogen peroxide
cellular response to hypoxia
ion transmembrane transport
manganese ion transport
negative regulation of dendrite morphogenesis
platelet activation
positive regulation of calcium ion transport
positive regulation of cytosolic calcium ion concentration
positive regulation of ion transmembrane transporter activity
positive regulation of neuron differentiation
positive regulation of peptidyl-threonine phosphorylation
regulation of cytosolic calcium ion concentration
single fertilization
transmembrane transport - Gene Ontology Biological Process:
- aging
axon guidance
blood coagulation
calcium ion transmembrane transport
cation transport
cellular response to hydrogen peroxide
cellular response to hypoxia
ion transmembrane transport
manganese ion transport
negative regulation of dendrite morphogenesis
platelet activation
positive regulation of calcium ion transport
positive regulation of cytosolic calcium ion concentration
positive regulation of ion transmembrane transporter activity
positive regulation of neuron differentiation
positive regulation of peptidyl-threonine phosphorylation
regulation of cytosolic calcium ion concentration
single fertilization
transmembrane transport - Gene Ontology Molecular Function:
- inositol 1,4,5 trisphosphate binding
store-operated calcium channel activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
integral component of plasma membrane
membrane
plasma membrane
slit diaphragm - Keywords:
- ANK repeat
Alternative splicing
Calcium
Calcium channel
Calcium transport
Complete proteome
Disease mutation
Glycoprotein
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport - Interacts With:
- P20591