Names & Taxonomy
- Uniprot ID:
- Q9UQQ1
- Entry Name:
- NALDL_HUMAN
- Status:
- reviewed
- Protein Names:
- N-acetylated-alpha-linked acidic dipeptidase-like protein (NAALADase L) (EC 3.4.17.21) (100 kDa ileum brush border membrane protein) (I100) (Ileal dipeptidylpeptidase)
- Gene Names:
- NAALADL1 NAALADASEL NAALADL
- Gene Names Primary:
- NAALADL1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 740
- Sequence:
- MQWTKVLGLGLGAAALLGLGIILGHFAIPKKANSLAPQDLDLEILETVMGQLDAHRIRENLRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIVGPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQGIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLPPSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNGTLAPATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPDRYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGLIGSTEFTEEFFNKLQERTVAYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGDLSIYDNWIRYFNRSSPVYGLVPSLGSLGAGSDYAPFVHFLGISSMDIAYTYDRSKTSARIYPTYHTAFDTFDYVDKFLDPGFSSHQAVARTAGSVILRLSDSFFLPLKVSDYSETLRSFLQAAQQDLGALLEQHSISLGPLVTAVEKFEAEAAALGQRISTLQKGSPDPLQVRMLNDQLMLLERTFLNPRAFPEERYYSHVLWAPRTGSVVTFPGLSNACSRARDTASGSEAWAEVQRQLSIVVTALEGAAATLRPVADL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Apical cell membrane; Single-pass type II membrane protein. Note=Ileal brush border membrane.
Function
- Function:
- NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC (By similarity).
- Catalytic Activity:
- Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 416 416 Nucleophile; for NAALADase activity.
- Gene Ontology Go:
- apical plasma membrane
integral component of membrane
carboxypeptidase activity
dipeptidase activity
metal ion binding
metallopeptidase activity
peptidase activity - Gene Ontology Molecular Function:
- carboxypeptidase activity
dipeptidase activity
metal ion binding
metallopeptidase activity
peptidase activity - Gene Ontology Cellular Component:
- apical plasma membrane
integral component of membrane - Keywords:
- 3D-structure
Alternative splicing
Carboxypeptidase
Cell membrane
Complete proteome
Dipeptidase
Glycoprotein
Hydrolase
Membrane
Metal-binding
Metalloprotease
Multifunctional enzyme
Polymorphism
Protease
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix
Zinc