Names & Taxonomy
- Uniprot ID:
- Q9UQL6
- Entry Name:
- HDAC5_HUMAN
- Status:
- reviewed
- Protein Names:
- Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)
- Gene Names:
- HDAC5 KIAA0600
- Gene Names Primary:
- HDAC5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1122
- Sequence:
- MNSPNESDGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1.
Function
- Function:
- Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
- Catalytic Activity:
- Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
- Active Site:
- ACT_SITE 833 833
- Cross Reference Drug Bank:
- DB06603
- Gene Ontology Go:
- cytoplasm
Golgi apparatus
histone deacetylase complex
nucleoplasm
nucleus
chromatin binding
core promoter binding
histone deacetylase activity
histone deacetylase binding
metal ion binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
protein deacetylase activity
protein kinase C binding
repressing transcription factor binding
RNA polymerase III transcription factor binding
transcription factor binding
B cell activation
B cell differentiation
cellular response to insulin stimulus
cellular response to lipopolysaccharide
chromatin modification
chromatin organization
chromatin remodeling
chromatin silencing
histone deacetylation
inflammatory response
negative regulation of cell migration involved in sprouting angiogenesis
negative regulation of myotube differentiation
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
neuron differentiation
Notch signaling pathway
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription from RNA polymerase II promoter
protein deacetylation
regulation of gene expression, epigenetic
regulation of myotube differentiation
regulation of protein binding
response to activity
response to cocaine
response to drug
transcription, DNA-templated - Gene Ontology Biological Process:
- B cell activation
B cell differentiation
cellular response to insulin stimulus
cellular response to lipopolysaccharide
chromatin modification
chromatin organization
chromatin remodeling
chromatin silencing
histone deacetylation
inflammatory response
negative regulation of cell migration involved in sprouting angiogenesis
negative regulation of myotube differentiation
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
neuron differentiation
Notch signaling pathway
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription from RNA polymerase II promoter
protein deacetylation
regulation of gene expression, epigenetic
regulation of myotube differentiation
regulation of protein binding
response to activity
response to cocaine
response to drug
transcription, DNA-templated - Gene Ontology Molecular Function:
- chromatin binding
core promoter binding
histone deacetylase activity
histone deacetylase binding
metal ion binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
protein deacetylase activity
protein kinase C binding
repressing transcription factor binding
RNA polymerase III transcription factor binding
transcription factor binding - Gene Ontology Cellular Component:
- cytoplasm
Golgi apparatus
histone deacetylase complex
nucleoplasm
nucleus - Keywords:
- Acetylation
Alternative splicing
Chromatin regulator
Complete proteome
Cytoplasm
Hydrolase
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repressor
Transcription
Transcription regulation
Ubl conjugation
Zinc - Interacts With:
- Q9HCU9; P08393; Q13761; P31947; P63104