Names & Taxonomy

Uniprot ID:
Q9UQL6
Entry Name:
HDAC5_HUMAN
Status:
reviewed
Protein Names:
Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)
Gene Names:
HDAC5 KIAA0600
Gene Names Primary:
HDAC5
Organism:
Homo sapiens (Human)

Structure

Length:
1122
Sequence:
MNSPNESDGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1.

Function

Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Catalytic Activity:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Active Site:
ACT_SITE 833 833
Cross Reference Drug Bank:
DB06603
Gene Ontology Go:
cytoplasm
Golgi apparatus
histone deacetylase complex
nucleoplasm
nucleus
chromatin binding
core promoter binding
histone deacetylase activity
histone deacetylase binding
metal ion binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
protein deacetylase activity
protein kinase C binding
repressing transcription factor binding
RNA polymerase III transcription factor binding
transcription factor binding
B cell activation
B cell differentiation
cellular response to insulin stimulus
cellular response to lipopolysaccharide
chromatin modification
chromatin organization
chromatin remodeling
chromatin silencing
histone deacetylation
inflammatory response
negative regulation of cell migration involved in sprouting angiogenesis
negative regulation of myotube differentiation
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
neuron differentiation
Notch signaling pathway
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription from RNA polymerase II promoter
protein deacetylation
regulation of gene expression, epigenetic
regulation of myotube differentiation
regulation of protein binding
response to activity
response to cocaine
response to drug
transcription, DNA-templated
Gene Ontology Biological Process:
B cell activation
B cell differentiation
cellular response to insulin stimulus
cellular response to lipopolysaccharide
chromatin modification
chromatin organization
chromatin remodeling
chromatin silencing
histone deacetylation
inflammatory response
negative regulation of cell migration involved in sprouting angiogenesis
negative regulation of myotube differentiation
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
neuron differentiation
Notch signaling pathway
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription from RNA polymerase II promoter
protein deacetylation
regulation of gene expression, epigenetic
regulation of myotube differentiation
regulation of protein binding
response to activity
response to cocaine
response to drug
transcription, DNA-templated
Gene Ontology Molecular Function:
chromatin binding
core promoter binding
histone deacetylase activity
histone deacetylase binding
metal ion binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
protein deacetylase activity
protein kinase C binding
repressing transcription factor binding
RNA polymerase III transcription factor binding
transcription factor binding
Gene Ontology Cellular Component:
cytoplasm
Golgi apparatus
histone deacetylase complex
nucleoplasm
nucleus
Keywords:
Acetylation
Alternative splicing
Chromatin regulator
Complete proteome
Cytoplasm
Hydrolase
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repressor
Transcription
Transcription regulation
Ubl conjugation
Zinc
Interacts With:
Q9HCU9; P08393; Q13761; P31947; P63104

Publication

PubMed ID:
10220385 9628581 12168954 16625196 15489334 9610721 11018260 10898795 11081517 11114197 11509672 12354939 12504096 17373667 17872950 18184930 18332134 19666599 19608861 20188095 21269460 24413532 24275569