Names & Taxonomy
- Uniprot ID:
- Q9UNX9
- Entry Name:
- KCJ14_HUMAN
- Status:
- reviewed
- Protein Names:
- ATP-sensitive inward rectifier potassium channel 14 (Inward rectifier K(+) channel Kir2.4) (IRK-4) (Potassium channel, inwardly rectifying subfamily J member 14)
- Gene Names:
- KCNJ14 IRK4
- Gene Names Primary:
- KCNJ14
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 436
- Sequence:
- MGLARALRRLSGALDSGDSRAGDEEEAGPGLCRNGWAPAPVQSPVGRRRGRFVKKDGHCNVRFVNLGGQGARYLSDLFTTCVDVRWRWMCLLFSCSFLASWLLFGLAFWLIASLHGDLAAPPPPAPCFSHVASFLAAFLFALETQTSIGYGVRSVTEECPAAVAAVVLQCIAGCVLDAFVVGAVMAKMAKPKKRNETLVFSENAVVALRDHRLCLMWRVGNLRRSHLVEAHVRAQLLQPRVTPEGEYIPLDHQDVDVGFDGGTDRIFLVSPITIVHEIDSASPLYELGRAELARADFELVVILEGMVEATAMTTQCRSSYLPGELLWGHRFEPVLFQRGSQYEVDYRHFHRTYEVPGTPVCSAKELDERAEQASHSLKSSFPGSLTAFCYENELALSCCQEEDEDDETEEGNGVETEDGAASPRVLTPTLALTLPP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
- Intramembrane:
- INTRAMEM 134 145 Helical; Pore-forming; Name=H5.
Function
- Function:
- Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity).
- Cross Reference Drug Bank:
- DB01392
- Gene Ontology Go:
- dendrite
neuronal cell body
plasma membrane
voltage-gated potassium channel complex
inward rectifier potassium channel activity
cardiac conduction
potassium ion import
synaptic transmission - Gene Ontology Biological Process:
- cardiac conduction
potassium ion import
synaptic transmission - Gene Ontology Molecular Function:
- inward rectifier potassium channel activity
- Gene Ontology Cellular Component:
- dendrite
neuronal cell body
plasma membrane
voltage-gated potassium channel complex - Keywords:
- Complete proteome
Ion channel
Ion transport
Membrane
Polymorphism
Potassium
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel