Names & Taxonomy
- Uniprot ID:
- Q9UNN8
- Entry Name:
- EPCR_HUMAN
- Status:
- reviewed
- Protein Names:
- Endothelial protein C receptor (Activated protein C receptor) (APC receptor) (Endothelial cell protein C receptor) (CD antigen CD201)
- Gene Names:
- PROCR EPCR
- Gene Names Primary:
- PROCR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 238
- Sequence:
- MLTTLLPILLLSGWAFCSQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEGPDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCELPPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELREFLEDTCVQYVQKHISAENTKGSQTSRSYTSLVLGVLVGSFIIAGVAVGIFLCTGGRRC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.
- Cross Reference Drug Bank:
- DB00055
- Gene Ontology Go:
- cell surface
centrosome
extracellular exosome
extracellular region
focal adhesion
integral component of plasma membrane
plasma membrane
receptor activity
blood coagulation
immune response
leukocyte migration
negative regulation of coagulation - Gene Ontology Biological Process:
- blood coagulation
immune response
leukocyte migration
negative regulation of coagulation - Gene Ontology Molecular Function:
- receptor activity
- Gene Ontology Cellular Component:
- cell surface
centrosome
extracellular exosome
extracellular region
focal adhesion
integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Blood coagulation
Complete proteome
Disulfide bond
Glycoprotein
Hemostasis
Membrane
Polymorphism
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P25116