Names & Taxonomy

Uniprot ID:
Q9UNN8
Entry Name:
EPCR_HUMAN
Status:
reviewed
Protein Names:
Endothelial protein C receptor (Activated protein C receptor) (APC receptor) (Endothelial cell protein C receptor) (CD antigen CD201)
Gene Names:
PROCR EPCR
Gene Names Primary:
PROCR
Organism:
Homo sapiens (Human)

Structure

Length:
238
Sequence:
MLTTLLPILLLSGWAFCSQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEGPDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCELPPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELREFLEDTCVQYVQKHISAENTKGSQTSRSYTSLVLGVLVGSFIIAGVAVGIFLCTGGRRC
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Function

Function:
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.
Cross Reference Drug Bank:
DB00055
Gene Ontology Go:
cell surface
centrosome
extracellular exosome
extracellular region
focal adhesion
integral component of plasma membrane
plasma membrane
receptor activity
blood coagulation
immune response
leukocyte migration
negative regulation of coagulation
Gene Ontology Biological Process:
blood coagulation
immune response
leukocyte migration
negative regulation of coagulation
Gene Ontology Molecular Function:
receptor activity
Gene Ontology Cellular Component:
cell surface
centrosome
extracellular exosome
extracellular region
focal adhesion
integral component of plasma membrane
plasma membrane
Keywords:
3D-structure
Blood coagulation
Complete proteome
Disulfide bond
Glycoprotein
Hemostasis
Membrane
Polymorphism
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix
Interacts With:
P25116

Publication

PubMed ID:
7929370 10397730 10570964 14702039 11780052 15489334 10681599 21269460 25944712 12034704