Names & Taxonomy
- Uniprot ID:
- Q9UNA0
- Entry Name:
- ATS5_HUMAN
- Status:
- reviewed
- Protein Names:
- A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAM-TS 5) (ADAM-TS5) (ADAMTS-5) (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 11) (ADAM-TS 11) (ADAMTS-11) (ADMP-2) (Aggrecanase-2)
- Gene Names:
- ADAMTS5 ADAMTS11 ADMP2
- Gene Names Primary:
- ADAMTS5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 930
- Sequence:
- MLLGWASLLLCAFRLPLAAVGPAATPAQDKAGQPPTAAAAAQPRRRQGEEVQERAEPPGHPHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGTSAPWRHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix
Function
- Function:
- Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.
- Catalytic Activity:
- Cleaves aggrecan at the 392-Glu-|-Ala-393 site.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 411 411
- Gene Ontology Go:
- endoplasmic reticulum lumen
extracellular region
extracellular space
proteinaceous extracellular matrix
extracellular matrix binding
heparin binding
integrin binding
metalloendopeptidase activity
metallopeptidase activity
zinc ion binding
cellular protein metabolic process
defense response to bacterium
extracellular matrix disassembly
extracellular matrix organization
post-translational protein modification
protein O-linked fucosylation
protein O-linked glycosylation
proteolysis - Gene Ontology Biological Process:
- cellular protein metabolic process
defense response to bacterium
extracellular matrix disassembly
extracellular matrix organization
post-translational protein modification
protein O-linked fucosylation
protein O-linked glycosylation
proteolysis - Gene Ontology Molecular Function:
- extracellular matrix binding
heparin binding
integrin binding
metalloendopeptidase activity
metallopeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- endoplasmic reticulum lumen
extracellular region
extracellular space
proteinaceous extracellular matrix - Keywords:
- 3D-structure
Cleavage on pair of basic residues
Complete proteome
Disulfide bond
Extracellular matrix
Glycoprotein
Hydrolase
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Signal
Zinc
Zymogen - Interacts With:
- P13608