Names & Taxonomy
- Uniprot ID:
- Q9ULZ9
- Entry Name:
- MMP17_HUMAN
- Status:
- reviewed
- Protein Names:
- Matrix metalloproteinase-17 (MMP-17) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (MTMMP4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP) (MT4MMP)
- Gene Names:
- MMP17 MT4MMP
- Gene Names Primary:
- MMP17
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 603
- Sequence:
- MRRRAARGPGPPPPGPGLSRLPLPLLLLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFGYLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPPGGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQSPLWRGVPSTLDDAMRWSDGASYFFRGQEYWKVLDGELEVAPGYPQSTARDWLVCGDSQADGSVAAGVDAAEGPRAPPGQHDQSRSEDGYEVCSCTSGASSPPGAPGPLVAATMLLLLPPLSPGALWTAAQALTL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform Long: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.
Function
- Function:
- Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.
- Catalytic Activity:
- Cleaves pro-TNF-alpha at the 74-Ala-|-Gln-75 site.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 249 249
- Cross Reference Drug Bank:
- DB00786
- Gene Ontology Go:
- anchored component of membrane
integral component of plasma membrane
proteinaceous extracellular matrix
calcium ion binding
enzyme activator activity
metalloendopeptidase activity
zinc ion binding
positive regulation of catalytic activity - Gene Ontology Biological Process:
- positive regulation of catalytic activity
- Gene Ontology Molecular Function:
- calcium ion binding
enzyme activator activity
metalloendopeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- anchored component of membrane
integral component of plasma membrane
proteinaceous extracellular matrix - Keywords:
- Alternative splicing
Calcium
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Disulfide bond
Extracellular matrix
GPI-anchor
Glycoprotein
Hydrolase
Lipoprotein
Membrane
Metal-binding
Metalloprotease
Protease
Reference proteome
Repeat
Secreted
Signal
Zinc
Zymogen