Names & Taxonomy

Uniprot ID:
Q9ULZ9
Entry Name:
MMP17_HUMAN
Status:
reviewed
Protein Names:
Matrix metalloproteinase-17 (MMP-17) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (MTMMP4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP) (MT4MMP)
Gene Names:
MMP17 MT4MMP
Gene Names Primary:
MMP17
Organism:
Homo sapiens (Human)

Structure

Length:
603
Sequence:
MRRRAARGPGPPPPGPGLSRLPLPLLLLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFGYLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPPGGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQSPLWRGVPSTLDDAMRWSDGASYFFRGQEYWKVLDGELEVAPGYPQSTARDWLVCGDSQADGSVAAGVDAAEGPRAPPGQHDQSRSEDGYEVCSCTSGASSPPGAPGPLVAATMLLLLPPLSPGALWTAAQALTL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Isoform Long: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.

Function

Function:
Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.
Catalytic Activity:
Cleaves pro-TNF-alpha at the 74-Ala-|-Gln-75 site.
Cofactor:
COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Active Site:
ACT_SITE 249 249
Cross Reference Drug Bank:
DB00786
Gene Ontology Go:
anchored component of membrane
integral component of plasma membrane
proteinaceous extracellular matrix
calcium ion binding
enzyme activator activity
metalloendopeptidase activity
zinc ion binding
positive regulation of catalytic activity
Gene Ontology Biological Process:
positive regulation of catalytic activity
Gene Ontology Molecular Function:
calcium ion binding
enzyme activator activity
metalloendopeptidase activity
zinc ion binding
Gene Ontology Cellular Component:
anchored component of membrane
integral component of plasma membrane
proteinaceous extracellular matrix
Keywords:
Alternative splicing
Calcium
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Disulfide bond
Extracellular matrix
GPI-anchor
Glycoprotein
Hydrolase
Lipoprotein
Membrane
Metal-binding
Metalloprotease
Protease
Reference proteome
Repeat
Secreted
Signal
Zinc
Zymogen

Publication

PubMed ID:
10471807 8640782 16541075 10551873 10567400 10543448