Names & Taxonomy
- Uniprot ID:
- Q9ULQ1
- Entry Name:
- TPC1_HUMAN
- Status:
- reviewed
- Protein Names:
- Two pore calcium channel protein 1 (Voltage-dependent calcium channel protein TPC1)
- Gene Names:
- TPCN1 KIAA1169 TPC1
- Gene Names Primary:
- TPCN1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 816
- Sequence:
- MAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome membrane
- Intramembrane:
- INTRAMEM 263 286 Helical; Pore-forming.
Function
- Function:
- Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane.
- Gene Ontology Go:
- endosome
endosome membrane
integral component of membrane
lysosomal membrane
lysosome
plasma membrane
identical protein binding
NAADP-sensitive calcium-release channel activity
voltage-gated calcium channel activity
ion transmembrane transport
membrane depolarization during action potential
positive regulation of autophagy
release of sequestered calcium ion into cytosol
transmembrane transport - Gene Ontology Biological Process:
- ion transmembrane transport
membrane depolarization during action potential
positive regulation of autophagy
release of sequestered calcium ion into cytosol
transmembrane transport - Gene Ontology Molecular Function:
- identical protein binding
NAADP-sensitive calcium-release channel activity
voltage-gated calcium channel activity - Gene Ontology Cellular Component:
- endosome
endosome membrane
integral component of membrane
lysosomal membrane
lysosome
plasma membrane - Keywords:
- Alternative splicing
Calcium
Calcium channel
Calcium transport
Coiled coil
Complete proteome
Endosome
Glycoprotein
Ion channel
Ion transport
Lysosome
Membrane
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel - Interacts With:
- Itself; O00165; Q8NHX9