Names & Taxonomy

Uniprot ID:
Q9ULQ1
Entry Name:
TPC1_HUMAN
Status:
reviewed
Protein Names:
Two pore calcium channel protein 1 (Voltage-dependent calcium channel protein TPC1)
Gene Names:
TPCN1 KIAA1169 TPC1
Gene Names Primary:
TPCN1
Organism:
Homo sapiens (Human)

Structure

Length:
816
Sequence:
MAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Lysosome membrane
Intramembrane:
INTRAMEM 263 286 Helical; Pore-forming.

Function

Function:
Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane.
Gene Ontology Go:
endosome
endosome membrane
integral component of membrane
lysosomal membrane
lysosome
plasma membrane
identical protein binding
NAADP-sensitive calcium-release channel activity
voltage-gated calcium channel activity
ion transmembrane transport
membrane depolarization during action potential
positive regulation of autophagy
release of sequestered calcium ion into cytosol
transmembrane transport
Gene Ontology Biological Process:
ion transmembrane transport
membrane depolarization during action potential
positive regulation of autophagy
release of sequestered calcium ion into cytosol
transmembrane transport
Gene Ontology Molecular Function:
identical protein binding
NAADP-sensitive calcium-release channel activity
voltage-gated calcium channel activity
Gene Ontology Cellular Component:
endosome
endosome membrane
integral component of membrane
lysosomal membrane
lysosome
plasma membrane
Keywords:
Alternative splicing
Calcium
Calcium channel
Calcium transport
Coiled coil
Complete proteome
Endosome
Glycoprotein
Ion channel
Ion transport
Lysosome
Membrane
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel
Interacts With:
Itself; O00165; Q8NHX9

Publication

PubMed ID:
19387438 10574461 12168954 14702039 16541075 15489334 19620632 24275569