Names & Taxonomy

Uniprot ID:
Q9UL51
Entry Name:
HCN2_HUMAN
Status:
reviewed
Protein Names:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2)
Gene Names:
HCN2 BCNG2
Gene Names Primary:
HCN2
Organism:
Homo sapiens (Human)

Structure

Length:
889
Sequence:
MDARGGGGRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEALPPEAADEGGPRGRLRSRDSSCGRPGTPGAASTAKGSPNGECGRGEPQCSPAGPEGPARGPKVSFSCRGAASGPAPGPGPAEEAGSEEAGPAGEPRGSQASFMQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPPPPPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASPGPPPPASPPGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSASQPSLPHGAPGPAASTRPASSSTPRLGPTPAARAAAPSPDRRDSASPGAAGGLDPQDSARSRLSSNL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane
Intramembrane:
INTRAMEM 414 435 Pore-forming; Name=Segment H5.

Function

Function:
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity).
Enzyme Regulation:
ENZYME REGULATION: Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. cAMP binding causes a conformation change that leads to the assembly of an active tetramer and channel opening. Channel activity is modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.
Gene Ontology Go:
integral component of plasma membrane
plasma membrane
voltage-gated potassium channel complex
cAMP binding
identical protein binding
intracellular cAMP activated cation channel activity
voltage-gated potassium channel activity
voltage-gated sodium channel activity
cell-cell signaling
cellular response to cAMP
cellular response to cGMP
potassium ion transmembrane transport
regulation of membrane potential
sodium ion transmembrane transport
synaptic transmission
Gene Ontology Biological Process:
cell-cell signaling
cellular response to cAMP
cellular response to cGMP
potassium ion transmembrane transport
regulation of membrane potential
sodium ion transmembrane transport
synaptic transmission
Gene Ontology Molecular Function:
cAMP binding
identical protein binding
intracellular cAMP activated cation channel activity
voltage-gated potassium channel activity
voltage-gated sodium channel activity
Gene Ontology Cellular Component:
integral component of plasma membrane
plasma membrane
voltage-gated potassium channel complex
Keywords:
3D-structure
Cell membrane
Complete proteome
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Potassium
Potassium channel
Potassium transport
Reference proteome
Sodium
Sodium channel
Sodium transport
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel
cAMP
cAMP-binding
Interacts With:
Itself

Publication

PubMed ID:
10524219 10228147 15057824 9630217 18669648 22006928